酒精性患者戒酒期间血清亚硝酸盐/硝酸盐（NOx）和丙二醛（MDA）水平升高。

Increased serum nitrite/nitrate (NOx) and malondialdehyde (MDA) levels during alcohol withdrawal in alcoholic patients.

作者信息

Yuksel N, Uzbay I T, Karakiliç H, Aki O E, Etik C, Erbaş D

出版信息

Pharmacopsychiatry. 2005 Mar;38(2):95-6. doi: 10.1055/s-2005-837809.

DOI:10.1055/s-2005-837809

Abstract

Serum nitrite/nitrate (NOx) and malondialdehyde (MDA) levels of 40 male alcoholic patients and 14 healthy male controls were investigated. Severity of alcohol withdrawal in alcoholic patients was evaluated by using the Clinical Institute Withdrawal Assessment for Alcohol (CIWA-Ar) scale just before taking the blood samples. NOx levels in serum samples were determined based on the reduction of nitrate to nitrite by vanadium chloride. MDA levels were also determined spectrophotometrically at 540 nm. The total CIWA-Ar score of alcohol-withdrawn patients was found to be 17.7. NOx and MDA levels were significantly increased in alcoholics during alcohol withdrawal as compared to control subjects. In conclusion, we observed increased serum NOx levels and lipid peroxidation during alcohol withdrawal in alcoholic patients.

摘要

对40名男性酒精性患者和14名健康男性对照者的血清亚硝酸盐/硝酸盐（NOx）和丙二醛（MDA）水平进行了研究。在采集血样前，使用酒精临床研究所戒断评估量表（CIWA-Ar）评估酒精性患者酒精戒断的严重程度。血清样本中的NOx水平基于氯化钒将硝酸盐还原为亚硝酸盐来测定。MDA水平也在540nm处通过分光光度法测定。发现酒精戒断患者的CIWA-Ar总分是17.7。与对照受试者相比，酒精性患者在酒精戒断期间的NOx和MDA水平显著升高。总之，我们观察到酒精性患者在酒精戒断期间血清NOx水平升高和脂质过氧化。