Pauley Heart Center, Virginia Commonwealth University, Room 285 Gateway Building, 2nd floor Gateway, 1200 E Marshall St, PO Box 980051, Richmond, VA, 23298-0051, USA.
Curr Cardiol Rep. 2020 Mar 30;22(5):30. doi: 10.1007/s11886-020-01279-0.
Each new troponin assay generation is more sensitive, with recent generation high-sensitivity troponin (hsTn) assays able to detect minimal myocardial injury, even in asymptomatic patients. PURPOSE OF THE REVIEW: We reviewed recent information on the use of hsTn assays for assessing acute and chronic cardiovascular disease. RECENT FINDINGS: hsTn is used for early emergency department diagnosis, accelerating early discharge with a low event rate comparable if not better than current strategies. Low levels of hsTn are detected in a variety of chronic cardiac and non-cardiac conditions, non-disease conditions including heart failure, chemotherapy, and others. These elevations identify a population at increased risk for long-term cardiovascular events. However, management strategies remain unclear. hsTn has substantial advantages in emergency department use. They hold promise for identifying subclinical cardiac disease, with the potential for earlier intervention with the possibility of decreasing disease progression. Additional studies, however, are needed to determine if this strategy will lead to improved outcomes.
每一代新的肌钙蛋白检测方法都更加灵敏，最近一代高敏肌钙蛋白（hsTn）检测方法甚至能够检测到无症状患者的微小心肌损伤。
我们综述了 hsTn 检测方法在评估急性和慢性心血管疾病方面的最新信息。
hsTn 用于早期急诊科诊断，可加速早期出院，且事件发生率与当前策略相当，甚至更好。hsTn 在多种慢性心脏和非心脏疾病以及非疾病情况下都会被检测到，包括心力衰竭、化疗等。这些升高表明患者存在长期心血管事件风险增加。然而，管理策略仍不明确。hsTn 在急诊科的使用具有显著优势。它们有可能识别出亚临床心脏疾病，从而有可能更早地进行干预，降低疾病进展的可能性。然而，还需要进一步的研究来确定这种策略是否会带来更好的结果。
