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一项分割面部随机对照研究比较了腔内射频辅助切除术与传统切除术治疗痤疮后瘢痕的疗效和安全性。

A split-face randomized controlled study comparing the efficacy and safety of intralesional radiofrequency-assisted subcision vs conventional subcision in postacne scars.

机构信息

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

出版信息

J Cosmet Dermatol. 2020 May;19(5):1086-1092. doi: 10.1111/jocd.13384. Epub 2020 Mar 31.

DOI:10.1111/jocd.13384
PMID:32233007
Abstract

BACKGROUND

Postacne scars have significant psychosocial distress among patients. Subcision is a well-known treatment modality specially for rolling type of acne scars, but is a crude mechanical process, which carries a risk of hematoma formation.

AIMS

To compare the efficacy and safety of radiofrequency-assisted subcision (rSubcision) with conventional subcision in postacne scars.

METHODS

In this randomized, split-face study, adult patients with postacne scars were randomized to receive either conventional subcision or rSubcision in 2 sessions, 4 weeks apart and followed up for 2 months. Outcome was measured using Goodman and Baron score (GBS), investigator global assessment (IGA) by two blinded dermatologists, and patient global assessment (PGA).

RESULTS

Seventeen out of 21 patients completed the treatment. Statistical analysis of the results was performed using SPSS 15.0 statistical software (SPSS). Patients in both the groups had significant improvement from baseline according to quantitative scoring (P = .0001), number of scars (P = .0001), IGA, and PGA. The improvement was comparable in both the groups according to GBS and IGA but better on rSubcision side in terms of PGA. Two patients developed small entry point burn during rSubcision which healed in one month and one developed persistent hematoma with conventional subcision.

CONCLUSIONS

Both modalities were comparable in terms of assessment scores and investigator assessment, but patients found improvement better on rSubcision side.

摘要

背景

痤疮瘢痕会给患者带来明显的心理社会困扰。皮下分离术是一种专门针对滚动型痤疮瘢痕的知名治疗方法,但它是一种粗糙的机械过程,有形成血肿的风险。

目的

比较射频辅助皮下分离术(rSubcision)与传统皮下分离术治疗痤疮后瘢痕的疗效和安全性。

方法

在这项随机、分面研究中,将成人痤疮后瘢痕患者随机分为两组,每组 10 例,分别接受传统皮下分离术或 rSubcision 治疗,间隔 4 周进行 2 次治疗,并随访 2 个月。使用 Goodman 和 Baron 评分(GBS)、两位盲法皮肤科医生的研究者总体评估(IGA)和患者总体评估(PGA)来评估疗效。

结果

21 例患者中有 17 例完成了治疗。使用 SPSS 15.0 统计软件(SPSS)对结果进行统计学分析。两组患者的定量评分(P=0.0001)、瘢痕数量(P=0.0001)、IGA 和 PGA 均较基线有显著改善。根据 GBS 和 IGA,两组的改善情况相当,但 PGA 方面 rSubcision 组的改善更好。两名患者在 rSubcision 过程中出现小的入点烧伤,一个月后愈合,一名患者在接受传统皮下分离术时出现持续血肿。

结论

两种方法在评估评分和研究者评估方面相当,但患者认为 rSubcision 组的改善更好。

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