采用自体富血小板血浆与联合皮下分离术和自体富血小板血浆治疗萎缩性痤疮瘢痕：一项对照性分面研究。
Treatment of atrophic acne scars using autologous platelet-rich plasma vs combined subcision and autologous platelet-rich plasma: A split-face comparative study.
机构信息
Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
出版信息
J Cosmet Dermatol. 2020 Feb;19(2):456-461. doi: 10.1111/jocd.13048. Epub 2019 Jun 26.
BACKGROUND
Multiple therapeutic approaches are usually required when treating atrophic acne scars. Subcision was reported to be of value in improving rolling scars. Autologous platelet-rich plasma (PRP) has recently been proposed as an adjuvant treatment option for atrophic acne scars with few reports evaluating its efficacy.
OBJECTIVE
Our objective was to compare the effect of intradermal injection of PRP vs combined PRP and subcision in the treatment of atrophic acne scars.
METHODS
Thirty patients with bilateral atrophic acne scars were enrolled. Each patient received three monthly sessions. Each side of the face was randomly treated either with intradermal PRP alone or with combined treatment with subcision followed by PRP injection. Patients were assessed at 3 and 6 months following the last treatment session. Evaluation of serial photographs was performed by two blinded investigators.
RESULTS
Platelet-rich plasma alone showed a better response, fewer side effects, and shorter downtime compared to combined subcision and PRP.
CONCLUSION
Autologous PRP injection can be a therapeutic option in the treatment of atrophic acne scars, with fewer complications and better tolerability than combined subcision and autologous PRP.
背景
治疗萎缩性痤疮瘢痕时通常需要多种治疗方法。有报道称皮下分离术对改善滚动瘢痕有价值。最近，自体富血小板血浆（PRP）被提议作为治疗萎缩性痤疮瘢痕的一种辅助治疗选择，但很少有研究评估其疗效。
目的
我们的目的是比较真皮内注射 PRP 与 PRP 联合皮下分离术治疗萎缩性痤疮瘢痕的效果。
方法
共纳入 30 例双侧萎缩性痤疮瘢痕患者。每位患者接受 3 次每月一次的治疗。面部两侧随机分别接受单独真皮内 PRP 治疗或皮下分离术联合 PRP 注射治疗。在最后一次治疗后 3 个月和 6 个月进行随访评估。两名盲法观察者对系列照片进行评估。
结果
与 PRP 联合皮下分离术相比，单独使用 PRP 显示出更好的疗效、更少的副作用和更短的恢复期。
结论
与 PRP 联合皮下分离术相比，自体 PRP 注射是治疗萎缩性痤疮瘢痕的一种治疗选择，具有更少的并发症和更好的耐受性。
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