Yi Xiao-Dong, Zhanf Yi-Ning, Xiao Shuai, Lei Xiao-Can
Department of Histology and Embryology, School of Basic Medical Sciences, Zunyi Medical University, Zunyi, Guizhou 563003, China.
Zhonghua Nan Ke Xue. 2019 Oct;25(10):923-927.
Testis has been reported to be a naturally oxygen-deprived organ. Lactate produced by glycolysis of Sertoli cells is an important source of energy in spermatogenic cells, which quickly provides adenosine triphosphate to meet the needs of rapidly proliferating spermatogenic cells for energy and substances. Wide attention has been drawn to the studies of energy metabolism and its regulatory mechanisms in normal spermatogenesis. It is essential to illuminate the regulation of glucose transport by glucose transporters in Sertoli cells, the catalysis of pyruvate to lactic acid by lactate dehydrogenase and the transport process of the single carboxylate transporter to lactic acid under the influence of different factors or diseases, which play important roles in ensuring the normal spermatogenesis and male reproductive function. This review summarizes the changes of energy metabolism in spermatogenesis and the mechanisms of endocrine factors, signaling pathways, miRNAs and protein acetylation regulating cell glycolysis, aiming to provide some important reference for the elucidation of the molecular metabolism of spermatogenesis and clinical treatment of relevant diseases.
据报道，睾丸是一个天然缺氧的器官。支持细胞通过糖酵解产生的乳酸是生精细胞重要的能量来源，能迅速提供三磷酸腺苷，以满足快速增殖的生精细胞对能量和物质的需求。正常精子发生过程中的能量代谢及其调控机制的研究已引起广泛关注。阐明支持细胞中葡萄糖转运蛋白对葡萄糖转运的调节、乳酸脱氢酶将丙酮酸催化为乳酸以及单羧酸转运蛋白在不同因素或疾病影响下对乳酸的转运过程至关重要，这些过程在确保正常精子发生和男性生殖功能中发挥着重要作用。本综述总结了精子发生过程中能量代谢的变化以及内分泌因子、信号通路、微小RNA和蛋白质乙酰化调节细胞糖酵解的机制，旨在为阐明精子发生的分子代谢及相关疾病的临床治疗提供重要参考。
