Thorell L H, d'Elia G
Department of Psychiatry, Faculty of Health Sciences, University Hospital, Linköping, Sweden.
Acta Psychiatr Scand. 1988 Aug;78(2):247-53. doi: 10.1111/j.1600-0447.1988.tb06332.x.
Electrodermal activity (EDA) was investigated in 28 patients when depressive and when in remission and in 28 matched and 59 unmatched healthy subjects. The follow-up period ranged from 3 to 37 months (median two years). All the EDA variables were significantly elevated at follow-up and did not differ significantly from the EDA of the matched healthy subjects. However, in patients with extremely low electrodermal responsivity (EDR) when depressed, including suicide attempters, EDA was significantly elevated, but did not reach the levels of the healthy subjects, except for one EDA variable. Further, patients with major depressive episode and a history of recurrent depression did not reach the EDR levels found in the healthy subjects. The results are interpreted as an indication that normalization of EDA does not parallel clinical recovery and may be extended for several months (perhaps years for the EDR), possibly indicating vulnerability to relapse. The data may also be interpreted that persons who are normally electrodermally hyporesponsive, may, when depressive, develop a state of extreme hyporesponsivity that seems to be linked to the ability to carry out a suicide attempt.
对28例抑郁症患者在抑郁发作期和缓解期进行了皮肤电活动（EDA）研究，并与28例匹配的健康受试者以及59例不匹配的健康受试者进行了对比。随访期为3至37个月（中位数为两年）。所有EDA变量在随访时均显著升高，且与匹配的健康受试者的EDA无显著差异。然而，在抑郁发作时皮肤电反应性（EDR）极低的患者中，包括自杀未遂者，EDA显著升高，但除一个EDA变量外，均未达到健康受试者的水平。此外，患有重度抑郁发作且有复发性抑郁病史的患者，其EDR水平未达到健康受试者的水平。研究结果表明，EDA的正常化与临床康复并不平行，可能会持续数月（EDR可能持续数年），这可能表明患者易复发。这些数据还可以解释为，正常情况下皮肤电反应性低的人，在抑郁时可能会发展为极度低反应性状态，这似乎与自杀未遂的能力有关。
