Truesdell Sharon L, Saunders Marnie M
The Bone Biomechanics and Mechanobiology Lab, Department of Biomedical Engineering, The University of Akron, Akron, OH, USA.
Math Biosci Eng. 2019 Nov 19;17(2):1233-1252. doi: 10.3934/mbe.2020063.
The purpose of this paper is to emphasize the need for more complex bone remodeling platforms that allow for investigations of intricate multicellular interactions that regulate this process. We discuss the efforts we have taken to develop lab-on-a-chip systems for bone remodeling and the motivation for pursuing more advanced multicellular models. Further, we discuss mathematical modeling opportunities that will allow experimental results to extend beyond the set laboratory conditions. We advocate for the development of an agent-based model comprised of multiple cellular automata of each bone cell type. In total, this work requires a combination of techniques from bone biology, microfluidics, cell mechanobiology, mechanics, and mathematical modeling. Thus, significant advancements within the field will require a collective contribution from a variety of research laboratories.
本文的目的是强调需要更复杂的骨重塑平台，以便能够研究调节这一过程的复杂多细胞相互作用。我们讨论了为开发用于骨重塑的芯片实验室系统所做的努力以及追求更先进的多细胞模型的动机。此外，我们还讨论了数学建模机会，这些机会将使实验结果能够超越既定的实验室条件。我们主张开发一种基于代理的模型，该模型由每种骨细胞类型的多个细胞自动机组成。总的来说，这项工作需要结合骨生物学、微流体学、细胞机械生物学、力学和数学建模等技术。因此，该领域的重大进展将需要各个研究实验室的共同贡献。
