Mei Yu-Dan, Li Hai-Bo, Liu Ling-Xian, Shi Dan-Feng, Pan Da-Bo, Yao Xin-Sheng, Yu Yang
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, People's Republic of China.
Jiangsu Kanion Pharmaceutical Co. Ltd. and State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Jiangsu, Lianyungang, People's Republic of China.
Nat Prod Res. 2021 Oct;35(20):3432-3438. doi: 10.1080/14786419.2019.1705819. Epub 2020 Mar 31.
A new nitrogen-containing iridoid glycoside, named (7 ,3'-lonijapospiroside A (), together with thirteen known iridoid glycosides, were isolated from the flower buds of . The structures of these compounds were established on the basis of spectroscopic analyses. Among them, compounds are four diastereoisomers, and their absolute configurations were accurately established by the NOE spectra as well as comparison of their experimental and calculated ECD spectra. The anti-inflammatory activities of all isolates were evaluated by measuring their inhibitory effects on NO, IL-6, and TNF- production in LPS stimulated RAW 264.7 macrophages. Compound exhibited anti-inflammatory activities by inhibiting IL-6 with an IC value of 54.70 M, comparable to that of the positive control (hydrocortisone, IC: 62.6 ± 1.7 μM).
从[植物名称]的花芽中分离出一种新的含氮环烯醚萜苷，命名为(7 ,3'-洛尼加波斯皮罗苷A)，以及十三种已知的环烯醚萜苷。这些化合物的结构是基于光谱分析确定的。其中，化合物[具体化合物编号]是四种非对映异构体，它们的绝对构型通过NOE光谱以及实验和计算ECD光谱的比较准确确定。通过测量所有分离物对LPS刺激的RAW 264.7巨噬细胞中NO、IL-6和TNF-产生的抑制作用来评估其抗炎活性。化合物[具体化合物编号]通过抑制IL-6表现出抗炎活性，IC值为54.70 μM，与阳性对照（氢化可的松，IC：62.6 ± 1.7 μM）相当。
