从齿叶玄参（Scrophularia dentata Royle ex Benth.）中分离得到的环烯醚萜苷及其抗炎活性。
Iridoid glycosides isolated from Scrophularia dentata Royle ex Benth. and their anti-inflammatory activity.
作者信息
Zhang Liuqiang, Zhu Tiantian, Qian Fei, Xu Jinwen, Dorje Gaawe, Zhao Zhili, Guo Fujiang, Li Yiming
机构信息
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
Murad Research Institute for Modernized Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
出版信息
Fitoterapia. 2014 Oct;98:84-90. doi: 10.1016/j.fitote.2014.07.005. Epub 2014 Jul 10.
Scrodentosides A-E (1-5), five new acylated iridoid glycosides, together with 19 known ones, were isolated from the whole plant of Scrophularia dentata Royle ex Benth. The structures of these isolated glycosides were elucidated by spectroscopic methods. Bioassay showed that compounds 7 and 11 had significant inhibitory effect against NF-κB activation with IC50 value of 43.7 μM and 1.02 μM respectively.
从玄参科植物齿叶玄参（Scrophularia dentata Royle ex Benth.）的全草中分离得到了5个新的酰化环烯醚萜苷类化合物玄参苷A-E（1-5）以及19个已知化合物。通过光谱方法阐明了这些分离得到的苷类化合物的结构。生物活性测定表明，化合物7和11对NF-κB的激活具有显著抑制作用，其IC50值分别为43.7 μM和1.02 μM。
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