Department of Chemistry, University of Nairobi, Nairobi, Kenya.
Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Dortmund, Germany.
Nat Prod Res. 2021 Nov;35(22):4486-4493. doi: 10.1080/14786419.2020.1736065. Epub 2020 Mar 31.
A new flavone, named hildeflavone () along with 7 other known flavonoids were isolated from the aerial parts of Vatke. Their characterisation was based on NMR and MS data analysis. The anti-inflammatory properties of the crude extract, isolated compounds and combination of the compounds were investigated in lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMCs). Treatment of the LPS-stimulated PBMCs with the isolated flavonoids at a concentration of 100 µM significantly reduced the production of interleukins (IL-1β, IL-2 and IL-6), interferon-gamma (IFN-γ), granulocyte macrophage-colony stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-α). It was also found that the combination of a flavone and flavanones exhibited remarkable synergistic anti-inflammatory effects on the production of the cytokines.[Figure: see text].
从 Vatke 的地上部分分离得到一种新的黄酮类化合物，命名为 hildeflavone ()，以及其他 7 种已知的类黄酮。其结构特征基于 NMR 和 MS 数据分析。对粗提物、分离得到的化合物及其混合物的抗炎特性进行了研究，方法是用脂多糖（LPS）刺激外周血单核细胞（PBMC）。将分离得到的黄酮类化合物在 100 μM 的浓度下处理 LPS 刺激的 PBMC，可显著降低白细胞介素（IL-1β、IL-2 和 IL-6）、干扰素-γ（IFN-γ）、粒细胞巨噬细胞集落刺激因子（GM-CSF）和肿瘤坏死因子-α（TNF-α）的产生。还发现，一种黄酮类化合物和一种黄烷酮的组合对细胞因子的产生表现出显著的协同抗炎作用。[图：见正文]。
