Becker Mike
Klinik für Rheumatologie, Universitätsspital Zürich, Zürich.
Praxis (Bern 1994). 2020;109(5):347-354. doi: 10.1024/1661-8157/a003444.
Polymyalgia rheumatica and Giant Cell Arteritis - Update on Diagnosis and Therapy Polymyalgia rheumatica (PMR) is an inflammatory syndrome which often co-incides with giant cell arteritis (GCA). Due to unspecific symptoms and a plethora of possible alternative diagnoses, PMR often represents a diagnostic challenge. The use of ultrasound, but also other imaging methods has improved and accelerated the time to diagnosis in PMR and GCA, so that complications such as blindness can be reduced. Glucocorticoids are still the main initial therapy for both diseases. Although further research is needed concerning prevention of and screening for long term complications for GCA, the efficacy of biologicals, namely tocilizumab, has markedly increased therapeutic options for GCA and allows for a reduction of side effects.
风湿性多肌痛和巨细胞动脉炎——诊断与治疗的最新进展 风湿性多肌痛(PMR)是一种炎症综合征,常与巨细胞动脉炎(GCA)同时出现。由于症状不具特异性且存在众多可能的替代诊断,PMR常常构成诊断挑战。超声以及其他成像方法的应用改善并加快了PMR和GCA的诊断时间,从而能够减少诸如失明等并发症。糖皮质激素仍然是这两种疾病的主要初始治疗方法。尽管对于GCA的长期并发症的预防和筛查还需要进一步研究,但生物制剂(即托珠单抗)的疗效显著增加了GCA的治疗选择,并有助于减少副作用。