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择期血管内动脉瘤修复术前心肺运动试验和超声心动图的作用。

The role of cardiopulmonary exercise testing and echocardiography prior to elective endovascular aneurysm repair.

作者信息

Straw S, Waduud M A, Drozd M, Warman P, Bailey M A, Hammond C J, Abdel-Rahman Sed, Witte K K, Scott Dja

机构信息

University of Leeds, UK.

Leeds Teaching Hospitals NHS Trust, UK.

出版信息

Ann R Coll Surg Engl. 2020 May;102(5):383-390. doi: 10.1308/rcsann.2020.0045. Epub 2020 Apr 1.

DOI:10.1308/rcsann.2020.0045
PMID:32233869
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7374776/
Abstract

INTRODUCTION

Cardiopulmonary exercise testing (CPET) and transthoracic echocardiography (TTE) are common preparative investigations prior to elective endovascular aneurysm repair (EVAR). Whether these investigations can predict survival following EVAR and contribute to shared decision making is unknown.

METHODS

Patients who underwent EVAR at a tertiary centre between June 2007 and December 2014 were identified from the National Vascular Registry. Variables obtained from preoperative investigations were assessed for their association with survival at three years. Regression analysis was used to determine variables that independently predicted survival at three years.

RESULTS

A total of 199 patients underwent EVAR during the study period. Of these, 120 had preoperative CPET and 123 had TTE. Lower forced expiratory ventilation (FEV), ratio of FEV to forced vital capacity, work at peak oxygen consumption and higher ventilatory equivalent for carbon dioxide were associated with increased mortality. Variables obtained from TTE were not associated with survival at three years although there was a low incidence of left ventricular systolic dysfunction and significant valvular disease in this cohort.

CONCLUSIONS

CPET might be a useful adjunct to assist in shared decision making in patients undergoing elective EVAR and may influence anaesthetic technique. TTE does not appear to be able to discriminate between high and low risk individuals. However, a low rate of significant ventricular dysfunction and valvular disease in patients undergoing elective EVAR may account for these findings.

摘要

引言

心肺运动试验(CPET)和经胸超声心动图(TTE)是择期血管内动脉瘤修复术(EVAR)前常见的准备性检查。这些检查能否预测EVAR后的生存率并有助于共同决策尚不清楚。

方法

从国家血管登记处识别出2007年6月至2014年12月在一家三级中心接受EVAR的患者。评估术前检查获得的变量与三年生存率的相关性。采用回归分析确定独立预测三年生存率的变量。

结果

在研究期间,共有199例患者接受了EVAR。其中,120例患者术前行CPET,123例患者术前行TTE。较低的用力呼气通气量(FEV)、FEV与用力肺活量的比值、峰值耗氧量时的做功以及较高的二氧化碳通气当量与死亡率增加相关。尽管该队列中左心室收缩功能障碍和严重瓣膜病的发生率较低,但从TTE获得的变量与三年生存率无关。

结论

CPET可能是一种有用的辅助手段,有助于在接受择期EVAR的患者中进行共同决策,并可能影响麻醉技术。TTE似乎无法区分高风险和低风险个体。然而,择期EVAR患者中显著心室功能障碍和瓣膜病的发生率较低可能解释了这些结果。

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本文引用的文献

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Endovascular Repair of Abdominal Aortic Aneurysm in Patients Physically Ineligible for Open Repair: Very Long-term Follow-up in the EVAR-2 Randomized Controlled Trial.血管内修复术治疗身体状况不适合开放修复的腹主动脉瘤患者:EVAR-2 随机对照试验的极长期随访结果。
Ann Surg. 2017 Nov;266(5):713-719. doi: 10.1097/SLA.0000000000002392.
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Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years.对来自EVAR-1、DREAM、OVER和ACE试验的个体患者数据进行荟萃分析,比较腹主动脉瘤血管内修复或开放修复5年的结果。
Br J Surg. 2017 Feb;104(3):166-178. doi: 10.1002/bjs.10430.
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Endovascular versus open repair of abdominal aortic aneurysm in 15-years' follow-up of the UK endovascular aneurysm repair trial 1 (EVAR trial 1): a randomised controlled trial.英国血管内动脉瘤修复试验 1(EVAR 试验 1)15 年随访的血管内与开放修复腹主动脉瘤的比较:一项随机对照试验。
Lancet. 2016 Nov 12;388(10058):2366-2374. doi: 10.1016/S0140-6736(16)31135-7. Epub 2016 Oct 12.
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Transthoracic Echocardiography Provides Important Long-Term Prognostic Information in Selected Patients Undergoing Endovascular Abdominal Aortic Repair.经胸超声心动图为接受血管腔内腹主动脉修复术的特定患者提供重要的长期预后信息。
Circ Cardiovasc Imaging. 2016 Feb;9(2):e003557. doi: 10.1161/CIRCIMAGING.115.003557.
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Role of cardiopulmonary exercise testing as a risk-assessment method in patients undergoing intra-abdominal surgery: a systematic review.心肺运动试验作为腹内手术患者风险评估方法的作用:一项系统综述
Br J Anaesth. 2016 Feb;116(2):177-91. doi: 10.1093/bja/aev454.
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Cardiopulmonary exercise testing and survival after elective abdominal aortic aneurysm repair†.择期腹主动脉瘤修复术后心肺运动试验与生存†。
Br J Anaesth. 2015 Mar;114(3):430-6. doi: 10.1093/bja/aeu383. Epub 2014 Dec 5.
7
Risk stratification by pre-operative cardiopulmonary exercise testing improves outcomes following elective abdominal aortic aneurysm surgery: a cohort study.术前心肺运动试验的风险分层可改善择期腹主动脉瘤手术的预后:一项队列研究。
Perioper Med (Lond). 2013 May 19;2(1):10. doi: 10.1186/2047-0525-2-10.
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The shortfall in long-term survival of patients with repaired thoracic or abdominal aortic aneurysms: retrospective case-control analysis of hospital episode statistics.修复的胸主动脉或腹主动脉瘤患者长期存活率不足:医院病例统计的回顾性病例对照分析。
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