Casazza J P, Freitas J, Stambuk D, Morgan M Y, Veech R L
Laboratory of Metabolism and Molecular Biology, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852.
Adv Alcohol Subst Abuse. 1988;7(3-4):33-5. doi: 10.1300/J251v07n03_05.
Plasma D,L-2,3-butanediol was measured in 53 controls and 50 patients with alcoholic cirrhosis, none of whom had measurable amounts of blood ethanol. Thirteen of 50 samples from patients with alcoholic cirrhosis had measurable D,L-2,3-butanediol. (range less than 5-154 microM). In one patient with alcoholic cirrhosis who had been abstinent from ethanol for over 5 years plasma levels of D,L-2,3-butanediol ranged between 154 and 211 microM over a one-year period. Only one of the 53 control subjects had detectable levels of D,L-2,3-butanediol. Although it has previously been reported that 2,3-butanediol is present in alcoholics consuming distilled spirits (Rutstein et al. (1983) Lancet ii, 534), this is the first report of the persistent presence of these compounds in alcoholics in the absence of ethanol. Clearly in abstinent alcoholics the presence of 2,3-butanediol is not due to the ingestion of undistilled spirits nor is it likely to arise directly from the metabolic products of ethanol. The presence of D,L-2,3-butanediol in patients with alcoholic cirrhosis and its absence in control subjects suggests that this compound may be a marker of some forms for alcoholism.
对53名对照者和50名酒精性肝硬化患者的血浆D，L-2，3-丁二醇进行了检测，这些患者均未检测到血液中有可测量的乙醇含量。50份酒精性肝硬化患者的样本中，有13份检测到了可测量的D，L-2，3-丁二醇（范围小于5 - 154微摩尔）。在一名戒酒超过5年的酒精性肝硬化患者中，其血浆D，L-2，3-丁二醇水平在一年时间内介于154至211微摩尔之间。53名对照者中只有1人检测到了可检测水平的D，L-2，3-丁二醇。尽管此前有报道称饮用蒸馏酒的酗酒者体内存在2，3-丁二醇（Rutstein等人，《柳叶刀》ii，534（1983年）），但这是首次报道在没有乙醇的情况下这些化合物在酗酒者体内持续存在。显然，在戒酒的酗酒者中，2，3-丁二醇的存在并非由于饮用未蒸馏的酒，也不太可能直接源于乙醇的代谢产物。酒精性肝硬化患者中存在D，L-2，3-丁二醇而对照者中不存在，这表明该化合物可能是某些形式酒精中毒的一个标志物。
