Department of Radiation Oncology, University of Lübeck, Lübeck, Germany
Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.
Anticancer Res. 2020 Apr;40(4):2257-2260. doi: 10.21873/anticanres.14188.
BACKGROUND/AIM: For treatment personalization in elderly cancer patients, survival prognoses should be considered. We developed an instrument to estimate survival of elderly patients with brain metastasis from gynecological cancer.
In 15 patients, whole-brain radiotherapy regimen, tumor site, age, Karnofsky performance score (KPS), number of brain metastases, extra-cerebral metastases and interval from diagnosis of gynecological cancer until radiotherapy were retrospectively evaluated for survival. Characteristics found significant on multivariate analysis were used for the instrument.
In the multivariate analysis, KPS ≥70% (hazard ratio=3.71, p=0.0499) and an interval ≥28 months (hazard ratio=3.71, p=0.030) were significantly associated with better survival. Based on these characteristics, patients received 0 (n=6), 1 (n=3) or 2 points (n=6). Six-month survival rates of the groups 0-1 and 2 points were 0% and 50%, respectively (p=0.007).
This instrument helps estimating survival in elderly patients with brain metastases from gynecological cancer and contributes to personalization of their treatment.
背景/目的：为了实现老年癌症患者的个体化治疗，应考虑生存预后。我们开发了一种工具来评估妇科癌症脑转移老年患者的生存情况。
对 15 名患者的全脑放疗方案、肿瘤部位、年龄、卡氏功能状态评分（KPS）、脑转移数量、颅外转移和从妇科癌症诊断到放疗的时间间隔进行回顾性评估，以预测生存。多变量分析中发现有意义的特征被用于该工具。
多变量分析显示，KPS≥70%（风险比=3.71，p=0.0499）和间隔时间≥28 个月（风险比=3.71，p=0.030）与更好的生存显著相关。基于这些特征，患者获得 0（n=6）、1（n=3）或 2 分（n=6）。0-1 分组和 2 分组的 6 个月生存率分别为 0%和 50%（p=0.007）。
该工具有助于评估妇科癌症脑转移老年患者的生存情况，有助于对其进行个体化治疗。
