一种用于指导医生评估妇科癌症脑转移老年患者生存情况的工具。

An Instrument to Guide Physicians when Estimating the Survival of Elderly Patients With Brain Metastasis from Gynecological Cancer.

机构信息

Department of Radiation Oncology, University of Lübeck, Lübeck, Germany

Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.

出版信息

Anticancer Res. 2020 Apr;40(4):2257-2260. doi: 10.21873/anticanres.14188.

DOI:10.21873/anticanres.14188

PMID:32234922

Abstract

BACKGROUND/AIM: For treatment personalization in elderly cancer patients, survival prognoses should be considered. We developed an instrument to estimate survival of elderly patients with brain metastasis from gynecological cancer.

PATIENTS AND METHODS

In 15 patients, whole-brain radiotherapy regimen, tumor site, age, Karnofsky performance score (KPS), number of brain metastases, extra-cerebral metastases and interval from diagnosis of gynecological cancer until radiotherapy were retrospectively evaluated for survival. Characteristics found significant on multivariate analysis were used for the instrument.

RESULTS

In the multivariate analysis, KPS ≥70% (hazard ratio=3.71, p=0.0499) and an interval ≥28 months (hazard ratio=3.71, p=0.030) were significantly associated with better survival. Based on these characteristics, patients received 0 (n=6), 1 (n=3) or 2 points (n=6). Six-month survival rates of the groups 0-1 and 2 points were 0% and 50%, respectively (p=0.007).

CONCLUSION

This instrument helps estimating survival in elderly patients with brain metastases from gynecological cancer and contributes to personalization of their treatment.

摘要

背景/目的：为了实现老年癌症患者的个体化治疗，应考虑生存预后。我们开发了一种工具来评估妇科癌症脑转移老年患者的生存情况。

患者与方法

对 15 名患者的全脑放疗方案、肿瘤部位、年龄、卡氏功能状态评分（KPS）、脑转移数量、颅外转移和从妇科癌症诊断到放疗的时间间隔进行回顾性评估，以预测生存。多变量分析中发现有意义的特征被用于该工具。

结果

多变量分析显示，KPS≥70%（风险比=3.71，p=0.0499）和间隔时间≥28 个月（风险比=3.71，p=0.030）与更好的生存显著相关。基于这些特征，患者获得 0（n=6）、1（n=3）或 2 分（n=6）。0-1 分组和 2 分组的 6 个月生存率分别为 0%和 50%（p=0.007）。