Department of Radiation Oncology, University of Lübeck, Lübeck, Germany
Faculty of Medicine, Hanoi Medical University, Hanoi, Vietnam.
Anticancer Res. 2020 Apr;40(4):2261-2264. doi: 10.21873/anticanres.14189.
BACKGROUND/AIM: Personalized therapies may improve outcomes in elderly patients with brain metastases from cancer of unknown primary (CUP). To contribute to this strategy, an instrument for judging their survival time was designed.
This retrospective study included 53 patients, aged ≥65 years and treated with whole-brain irradiation (WBI) for brain metastases from CUP. The WBI-program, age, gender, Karnofsky performance score (KPS), number of brain metastases and non-cerebral metastases were analyzed.
KPS≤60 (p<0.001) and presence of non-cerebral metastases (p=0.003) were significantly associated with unfavorable survival. These factors formed the basis for the prognostic implement; patient-scores of zero (n=23), one (n=21) or two points (n=9) were obtained. Corresponding survival rates at 6-months were 0%, 19% and 56% (p<0.001).
With this instrument, it is easier to judge the remaining survival time of elderly patients with brain metastases from CUP. This information should be used when selecting individual treatment- and WBI-programs.
背景/目的：针对癌症原发灶不明的脑转移瘤（CUP）老年患者，个体化治疗可能改善预后。为助力这一策略，我们设计了一种评估其生存时间的工具。
本回顾性研究纳入了 53 例年龄≥65 岁且接受全脑放疗（WBI）治疗的 CUP 脑转移瘤患者。分析了 WBI 方案、年龄、性别、卡氏功能状态评分（KPS）、脑转移瘤和非脑转移瘤数量。
KPS≤60（p<0.001）和存在非脑转移（p=0.003）与预后不良显著相关。这些因素构成了预后工具的基础；患者得分为 0 分（n=23）、1 分（n=21）或 2 分（n=9）。6 个月时的相应生存率分别为 0%、19%和 56%（p<0.001）。
通过该工具，我们更容易判断 CUP 脑转移瘤老年患者的剩余生存时间。在选择个体化治疗和 WBI 方案时，应参考这一信息。
