Kalousek D K, Bamforth S
Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Am J Med Genet. 1988 Sep;31(1):63-73. doi: 10.1002/ajmg.1320310110.
Amnion rupture sequence is considered an uncommon, sporadic condition among liveborn infants. We have examined 1,010 previable fetuses (9-20 weeks developmental age) to determine the incidence and nature of amnion rupture sequence at this stage of development. We found 18 affected fetuses (15 spontaneous and 3 induced abortions) with the incidence of 1:56. Eleven fetuses had limb constrictions and amputations only; 7 fetuses also had nonlimb involvement, including disruptions of the craniofacial region mimicking encephalocele, unusual facial clefts, and abdominal defects. In 6 pregnancies, constrictions of the umbilical cord by amniotic bands were the cause of fetal intrauterine death.
羊膜破裂序列被认为是活产婴儿中一种罕见的散发性疾病。我们检查了1010例未成熟胎儿（发育年龄9 - 20周），以确定在这个发育阶段羊膜破裂序列的发生率和性质。我们发现18例受影响的胎儿（15例自然流产和3例人工流产），发生率为1:56。11例胎儿仅有肢体收缩和截肢；7例胎儿还伴有非肢体受累，包括模仿脑膨出的颅面部区域破坏、异常面部裂隙和腹部缺陷。在6例妊娠中，羊膜带导致的脐带受压是胎儿宫内死亡的原因。
