Hunter A G, Carpenter B F
Am J Med Genet. 1986 Aug;24(4):691-700. doi: 10.1002/ajmg.1320240414.
It is widely accepted that the primary event in the amniotic band sequence (ABS) is early rupture of the amnion, and that the development of the fetus is then disrupted by entanglement and abrasion. The mechanism of the initial rupture is unknown. An argument raised in favor of this theory has been the apparent absence of non-band-derived malformations in the ABS. Here we report on four infants with ABS and additional malformations that are not readily explainable on the basis of band disruptions. These infants, together with some additional observations in the literature, and a growing number of reports of familial ABS, raise the question as to whether the formation of bands and other "non-disruption" abnormalities may have a common primary etiology in some cases. The primary mechanism could operate through disturbing the vascular system, and the factors involved might be both extrinsic or intrinsic, and some instances might date to an abnormality of the germ disk.
羊膜带序列（ABS）的主要事件是羊膜早期破裂，胎儿发育随后因缠绕和磨损而受到干扰，这一观点已被广泛接受。初始破裂的机制尚不清楚。支持该理论的一个论据是，在ABS中明显不存在非带源性畸形。在此，我们报告了4例患有ABS且伴有其他畸形的婴儿，这些畸形难以用带的破坏来解释。这些婴儿，连同文献中的一些其他观察结果，以及越来越多的家族性ABS报告，引发了一个问题，即在某些情况下，带的形成和其他“非破坏”异常是否可能有共同的原发性病因。主要机制可能通过干扰血管系统起作用，涉及的因素可能是外在的或内在的，有些情况可能可追溯到胚盘异常。
