PARCC, INSERM, Université de Paris Renal Division, Georges Pompidou European Hospital, Assistance Publique - Hôpitaux de Paris, Université de Paris, F-75015 Paris, France.
Curr Opin Nephrol Hypertens. 2020 May;29(3):293-301. doi: 10.1097/MNH.0000000000000600.
The recent years have been marked by the publication of several articles highlighting the pathophysiological role of glomerular parietal epithelial cells (PEC) and refining their phenotypic heterogeneity.
The present review synthetizes recent findings on (i) the potential regenerative role of PEC in glomerular diseases, and (ii) the mechanisms and signaling of leading to PEC pathogenic involvement in crescentic glomerulonephritis (CGN) and focal segmental glomerulosclerosis (FSGS).
The debate is still open regarding the podocyte regenerative properties of PEC in glomerular disease, whereas the pathogenic involvement of PEC activation in glomerular disease is increasingly admitted. Recent highlights on the podocyte regenerative role of PEC, on one hand, and on their pathological function, on the other hand, for sure will feed the debate in the kidney community for the next years. Nevertheless, from a therapeutic perspective, the two options, boosting cellular regeneration and blocking PECs pathogenicity, should not be seen as antagonistic but, rather, complementary.
近年来，多篇文章强调了肾小球壁细胞（PEC）的病理生理作用，并对其表型异质性进行了深入研究。
本综述综合了最近关于（i）PEC 在肾小球疾病中的潜在再生作用，以及（ii）导致 PEC 在新月体性肾小球肾炎（CGN）和局灶节段性肾小球硬化症（FSGS）中病理性参与的机制和信号的研究进展。
关于 PEC 在肾小球疾病中的足细胞再生特性，争议仍未解决，而 PEC 激活在肾小球疾病中的致病作用也越来越被认可。PEC 在足细胞再生中的作用以及在其病理功能方面的最新研究进展，无疑将在未来几年引发肾脏病学界的讨论。然而，从治疗的角度来看，促进细胞再生和阻断 PEC 致病性这两种方法不应被视为相互对立，而应相辅相成。
