III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Institut National de la Santé et de la Recherche Médicale (Inserm), Paris Cardiovascular Center - PARCC, Université de Paris, Paris, France.
Cell Tissue Res. 2021 Aug;385(2):345-354. doi: 10.1007/s00441-021-03513-9. Epub 2021 Aug 28.
Crescentic glomerulonephritis represents a group of kidney diseases characterized by rapid loss of kidney function and the formation of glomerular crescents. While the role of the immune system has been extensively studied in relation to the development of crescents, recent findings show that parietal epithelial cells play a key role in the pathophysiology of crescent formation, even in the absence of immune modulation. This review highlights our current understanding of parietal epithelial cell biology and the reported physiological and pathological roles that these cells play in glomerular lesion formation, especially in the context of crescentic glomerulonephritis.
新月体肾小球肾炎是一组以肾功能迅速丧失和肾小球新月体形成为特征的肾脏疾病。虽然免疫系统在新月体形成中的作用已被广泛研究，但最近的研究结果表明，壁层上皮细胞在新月体形成的病理生理学中发挥着关键作用，即使在没有免疫调节的情况下也是如此。这篇综述强调了我们目前对壁层上皮细胞生物学的理解，以及这些细胞在肾小球损伤形成中所扮演的生理和病理作用，特别是在新月体肾小球肾炎的背景下。
