Ruangaram Wijitrapha, Kato Eisuke
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita-ku, Sapporo, Hokkaido 060-8589, Japan.
Division of Fundamental AgriScience and Research, Research Faculty of Agriculture, Hokkaido University, Kita-ku, Sapporo, Hokkaido 060-8589, Japan.
Pharmaceuticals (Basel). 2020 Mar 29;13(4):56. doi: 10.3390/ph13040056.
The prevalence of obesity is increasing globally. Despite the availability of a variety of anti-obesogenic drugs, including therapies under clinical development, these treatments are often indicated for patients with severe obesity, making them unsuitable for patients with mild obesity or for preventative use. In Thailand, traditional remedies employing medicinal plants are widely used to maintain health and treat disease. These treatments are generally inexpensive and readily available at markets, making them good treatment options for preventing obesity. To evaluate the anti-obesogenic potential of Thai medicinal plants, we employed three in vitro methods: pancreatic lipase inhibition, lipolysis enhancement, and lipid accumulation reduction assays. Among 70 Thai medicinal plants, Jack, Diels, and (Willd.) DC. were selected as the most favorable candidates because they exhibited anti-obesogenic activity in all three assays. These medicinal plants are expected to have efficient anti-obesogenic effects, making them promising candidates for further study.
全球肥胖症的患病率正在上升。尽管有多种抗肥胖药物可供使用，包括正在临床开发的疗法，但这些治疗通常适用于重度肥胖患者，因此不适用于轻度肥胖患者或预防性使用。在泰国，使用药用植物的传统疗法被广泛用于维持健康和治疗疾病。这些治疗通常价格低廉且在市场上容易获得，使其成为预防肥胖的良好治疗选择。为了评估泰国药用植物的抗肥胖潜力，我们采用了三种体外方法：胰脂肪酶抑制、脂肪分解增强和脂质积累减少试验。在70种泰国药用植物中，Jack、Diels和(Willd.) DC.被选为最有潜力的候选植物，因为它们在所有三种试验中均表现出抗肥胖活性。这些药用植物有望具有有效的抗肥胖作用，使其成为进一步研究的有希望的候选植物。
