西墨西哥人群的 KIR/HLA 基因型多样性及其与寻常型银屑病的关联。

Diversity of KIR/HLA Genotypes and Their Association with Psoriasis Vulgaris in the Western Mexican Population.

机构信息

Doctorate in Biomedical Sciences, Department of Physiology, University Center of Health Sciences (CUCS), University of Guadalajara (UDG), Guadalajara, Jal. 44340, Mexico.

Laboratory of Biological Systems, Department of Health Sciences, University Center of the Valleys (CUVALLES), UDG, Ameca, Jal. 4660, Mexico.

出版信息

Genes (Basel). 2020 Mar 22;11(3):338. doi: 10.3390/genes11030338.

DOI:10.3390/genes11030338

PMID:32235781

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7141133/

Abstract

NK and some T cell functions are regulated by the interaction between KIR and HLA molecules. Several studies have shown an association between activating genes and the development of autoimmune diseases, including psoriasis vulgaris (PsV). Our objective was to determine the association between genes and genotypes with PsV in the Western mestizo Mexican population. One hundred subjects diagnosed with PsV (SP) and 108 healthy subjects (HS) were genotyped for 14 genes, , , and by PCR-single specific primer (SSP). Positive associations of the gene (odds ratio (OR) 1.959, = 0.021), G11 genotype (OR 19.940, = 0.008), and (OR 2.265, = 0.009) were found with susceptibility to PsV. In contrast, the G1 genotype (OR 0.448, = 0.031) and (OR 0.522, = 0.022) were negatively associated with susceptibility to this disease. These results suggest an implication of the genotype in PsV pathology.

摘要

自然杀伤细胞（NK）和一些 T 细胞功能受 KIR 和 HLA 分子相互作用的调节。几项研究表明，激活基因与包括寻常型银屑病（PsV）在内的自身免疫性疾病的发展之间存在关联。我们的目的是确定 14 个基因、、、和在西方梅斯蒂索墨西哥人群中与 PsV 的关联。对 100 名诊断为 PsV（SP）的患者和 108 名健康对照者（HS）进行了 14 个基因的 PCR-单特异性引物（SSP）基因分型，用于基因。发现基因（比值比（OR）1.959，=0.021）、G11 基因型（OR 19.940，=0.008）和（OR 2.265，=0.009）与 PsV 的易感性呈阳性关联。相比之下，G1 基因型（OR 0.448，=0.031）和（OR 0.522，=0.022）与该疾病的易感性呈负相关。这些结果表明基因型在 PsV 发病机制中的作用。