Department of Pharmaceutical Services, Samsung Medical Center, Seoul, Republic of Korea.
Department of Pharmacy, Kyung Hee University Hospital at Kangdong, Seoul, Republic of Korea.
PLoS One. 2020 Apr 1;15(4):e0230922. doi: 10.1371/journal.pone.0230922. eCollection 2020.
There have been no studies on the characteristics of parenteral nutrition (PN) supply for adult inpatients in South Korea. The aim of this retrospective multicenter cross sectional study was to investigate the current practice and characteristics of PN support in hospitalized adult patients in South Korea for the first time. This study was conducted retrospectively for the adult patients who were hospitalized and received PN in nine hospitals on August 1st, 2017 to October 30th, 2017. We evaluated the type of PN formulation, PN administration period, administration route, calories supplied, amount of protein supplied, and laboratory results. Among the 11,580 inpatient admissions on that day, 1,439 patients received PN (12.4%). The majority of enrolled patients (96.5%) used the commercial PN, of which 86.2% were multi-chamber. 71.2% of them received PN peripherally. The average in hospital PN duration was 17.8 ± 52.6 days. Patients received only 65.4 ± 25.4% calories of their target calories. The in-hospital mortality of enrolled patients was 22%. In South Korea, commercial PN was usually administered to hospitalized adult patients and in-hospital mortality in adult patients using PN was higher in South Korea compared to other countries. This study provides the characteristics and the PN support status of hospitalized adult patients receiving PN in South Korea.
韩国尚未开展针对成人住院患者肠外营养(PN)供应特点的研究。本回顾性多中心横断面研究的目的在于首次调查韩国住院成年患者 PN 支持的当前实践和特点。该研究回顾性分析了 2017 年 8 月 1 日至 2017 年 10 月 30 日期间在 9 家医院住院并接受 PN 的成年患者。我们评估了 PN 配方类型、PN 治疗时间、给药途径、热量供应、蛋白质供应量和实验室结果。当天的 11580 例住院患者中,有 1439 例(12.4%)接受 PN。纳入的大多数患者(96.5%)使用商业 PN,其中 86.2%为多腔袋。其中 71.2%经外周给药。平均住院 PN 时间为 17.8±52.6 天。患者仅接受了目标热量的 65.4±25.4%。纳入患者的院内死亡率为 22%。在韩国,商业 PN 通常用于住院成年患者,与其他国家相比,使用 PN 的韩国成年患者院内死亡率更高。本研究提供了韩国接受 PN 治疗的住院成年患者的特点和 PN 支持情况。