French D D, Klei T M, Foil C S, Miller R I, Foil L D, Chapman M R, McClure J J
Department of Veterinary Science, Louisiana Agricultural Experiment Station, Louisiana State University Agricultural Center, Baton Rouge 70803-6002.
Am J Vet Res. 1988 Sep;49(9):1550-4.
The efficacy of a single dose of ivermectin (0.2 mg/kg), in injectable or paste formulations, against microfilariae of Onchocerca cervicalis and associated skin lesions was evaluated in 20 naturally infected horses during midsummer months in Louisiana. All horses had clinical signs of dermatitis of the ventral midline and/or limbs, shoulders, thorax, and withers. Efficacy was monitored at 21, 42, and 63 days after treatment. Procedures done at these intervals included microfilarial counts of 6-mm skin biopsy specimens of affected ventral midline, grading of gross lesions, and photography and histologic assessment of ventral midline biopsy specimens. Microfilarial numbers were reduced to 0 by 21 days after treatment in all but one horse. Active lesions improved or were resolved completely by 63 days after treatment. Total inflammation, as judged by histologic methods, was reduced in all horses by 63 days after treatment, but there was a residual population of inflammatory cells in all horses. Adverse reactions after treatment were not observed in any of the horses.
在路易斯安那州盛夏时节，对20匹自然感染的马评估了单剂量伊维菌素（0.2毫克/千克）注射剂或膏剂对颈盘尾丝虫微丝蚴及相关皮肤病变的疗效。所有马匹均有腹中线和/或四肢、肩部、胸部及肩胛部皮炎的临床症状。在治疗后21天、42天和63天监测疗效。这些时间点进行的操作包括对受影响腹中线6毫米皮肤活检标本进行微丝蚴计数、对大体病变进行分级，以及对腹中线活检标本进行拍照和组织学评估。除一匹马外，所有马匹在治疗后21天微丝蚴数量均降至0。活动性病变在治疗后63天有所改善或完全消退。通过组织学方法判断，所有马匹在治疗后63天总炎症反应均减轻，但所有马匹均有残余炎症细胞群。治疗后未在任何一匹马中观察到不良反应。
