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基于数据挖掘的胃热炽盛型糖尿病中医方剂用药规律分析

[Analysis of medication regularity of traditional Chinese medicine prescriptions for gastropyretic excessiveness diabetes based on data mining].

作者信息

Wang Ye-Ran, Zhang Yang, Qin Qi-Bing, Wang Ping, Tan Long

机构信息

Heilongjiang University of Chinese Medicine Harbin 150040, China National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.

Heilongjiang University of Chinese Medicine Harbin 150040, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2020 Jan;45(1):196-201. doi: 10.19540/j.cnki.cjcmm.20191106.502.

Abstract

To analyze the medication regularity of traditional Chinese medicine(TCM) prescriptions for gastropyretic excessiveness diabetes recorded in Chinese Medicine Prescriptions Dictionary. A total of 103 eligible prescriptions were input into the system platform, and the Apriori algorithm was used to analyze their medication regularity. The 103 prescriptions for gastropyretic excessiveness diabetes were selected from the system, and 29 herb medicines were found with frequency of usage more than 8. Totally 33 commonly used herbal pairs(support degree≥10), twenty-three 3-herb core combinations(support degree≥8, confidence values≥0.5), and twenty-one 4-herb core combinations(confidence values≥0.5) were discovered after the medication regularity analysis by Apriori algorithm. The herbal medicine combinations with the highest correlation degree were discovered after the association rule analysis on the 103 prescriptions(support degree≥10, confidence values≥0.5). The four properties, five tastes, channel distributions and frequency of dose of the 103 prescriptions were also obtained after the corresponding analysis. According to the analysis and summary of the above data, the combination of Trichosanthis Radix, Anemarrhenae Rhizoma, Coptidis Rhizoma and Ophiopogonis Radix could reflect the medication regularity of TCM prescriptions for gastropyretic excessiveness diabetes to a certain degree, which is of great significance in guiding value in clinic.

摘要

分析《中药方剂大辞典》中记录的胃热炽盛型糖尿病的中医方剂用药规律。将103首符合条件的方剂录入系统平台,采用Apriori算法分析其用药规律。从系统中选取103首胃热炽盛型糖尿病方剂,发现使用频次超过8次的中药有29味。经Apriori算法进行用药规律分析后,共发现33对常用药对(支持度≥10)、23个三味核心组合(支持度≥8,置信度≥0.5)以及21个四味核心组合(置信度≥0.5)。对103首方剂进行关联规则分析(支持度≥10,置信度≥0.5)后,发现关联度最高的中药组合。对103首方剂进行相应分析后,还得出其性味、归经分布及用药剂量频次情况。根据上述数据的分析总结,天花粉、知母、黄连、麦冬的组合在一定程度上能反映胃热炽盛型糖尿病中医方剂的用药规律,对临床具有重要的指导价值。

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