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经 PCR 阳性下呼吸道标本诊断的输入性 COVID-19 病例,但咽拭子 PCR 阴性。

A case of imported COVID-19 diagnosed by PCR-positive lower respiratory specimen but with PCR-negative throat swabs.

机构信息

Department of Infectious Diseases, Japanese Red Cross Narita Hospital, Narita, Chiba, Japan.

Department of Infectious Diseases, Kameda Medical Center, Kamogawa, Chiba, Japan.

出版信息

Infect Dis (Lond). 2020 Jun;52(6):423-426. doi: 10.1080/23744235.2020.1744711. Epub 2020 Apr 2.

DOI:10.1080/23744235.2020.1744711
PMID:32238024
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7157961/
Abstract

A 35-year-old woman presented with fever and mild diarrhoea without any respiratory symptoms 9 days after travelling to Japan from Wuhan, China. Her computed tomography scan revealed pneumonia. The first polymerase chain reaction (PCR) test on throat swab for the novel corona virus upon admission was negative. Therefore, she was treated for community-acquired pneumonia, but fever persisted. On hospital day 5, PCR test on induced sputum was positive, but a second polymerase chain reaction test on throat swab remained negative. She was discharged, fully recovered, on hospital day 12. A lower respiratory tract specimen should be obtained for better diagnosis of corona virus disease 2019, even in the absence of respiratory symptoms for patients with significant travel or exposure history.

摘要

一位 35 岁女性,从中国武汉前往日本旅行 9 天后出现发热和轻度腹泻,但无呼吸道症状。她的计算机断层扫描显示肺炎。入院时,第一次针对新型冠状病毒的咽拭子聚合酶链反应(PCR)检测结果为阴性。因此,她被诊断为社区获得性肺炎进行治疗,但发热持续存在。入院第 5 天,诱导痰 PCR 检测结果为阳性,但第二次咽拭子 PCR 检测结果仍为阴性。入院第 12 天,她痊愈出院。对于有明确旅行史或暴露史的患者,即使没有呼吸道症状,也应获取下呼吸道标本以更好地诊断 2019 年冠状病毒病。

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