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严重急性呼吸综合征冠状病毒 2 型与儿科实体器官移植:已知和未知。

SARS-CoV-2 and pediatric solid organ transplantation: Current knowns and unknowns.

机构信息

Pediatric Infectious Diseases Unit, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.

Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, OH, USA.

出版信息

Pediatr Transplant. 2021 Aug;25(5):e13986. doi: 10.1111/petr.13986. Epub 2021 Mar 10.

Abstract

The COVID-19 pandemic has proven to be a challenge in regard to the clinical presentation, prevention, diagnosis, and management of SARS-CoV-2 infection among children who are candidates for and recipients of SOT. By providing scenarios and frequently asked questions encountered in routine clinical practice, this document provides expert opinion and summarizes the available data regarding the prevention, diagnosis, and management of SARS-CoV-2 infection among pediatric SOT candidates and recipients and highlights ongoing knowledge gaps requiring further study. Currently available data are still lacking in the pediatric SOT population, but data have emerged in both the adult SOT and general pediatric population regarding the approach to COVID-19. The document provides expert opinion regarding prevention, diagnosis, and management of SARS-CoV-2 infection among pediatric SOT candidates and recipients.

摘要

COVID-19 大流行对儿童器官移植候选者和受者 SARS-CoV-2 感染的临床表现、预防、诊断和管理带来了挑战。本文件通过提供常规临床实践中遇到的场景和常见问题,提供了专家意见,并总结了有关儿科器官移植候选者和受者 SARS-CoV-2 感染预防、诊断和管理的现有数据,并强调了需要进一步研究的持续存在的知识空白。目前儿科器官移植人群的数据仍然缺乏,但在成人器官移植和一般儿科人群中已经出现了有关 COVID-19 处理方法的数据。本文件就儿科器官移植候选者和受者 SARS-CoV-2 感染的预防、诊断和管理提供了专家意见。

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本文引用的文献

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Emergence of a Highly Fit SARS-CoV-2 Variant.一种高度适应的严重急性呼吸综合征冠状病毒2变体的出现。
N Engl J Med. 2020 Dec 31;383(27):2684-2686. doi: 10.1056/NEJMcibr2032888. Epub 2020 Dec 16.
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Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19.巴瑞替尼联合瑞德西韦治疗住院的新冠成年患者
N Engl J Med. 2021 Mar 4;384(9):795-807. doi: 10.1056/NEJMoa2031994. Epub 2020 Dec 11.
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