Department of Biotechnology, Graduate School of Engineering, Toyama Prefectural University.
Research Fellow of Japan Society for the Promotion of Science (JSPS).
Biol Pharm Bull. 2020;43(4):596-607. doi: 10.1248/bpb.b19-00858.
Lipoproteins are naturally occurring nanoparticles and their main physiological function is the promotion of lipid metabolism. They can be prepared in vitro for use as drug carriers, and these reconstituted lipoproteins show similar biological activity to their natural counterparts. Some lipoproteins can cross the blood-retinal barrier and are involved in intraocular lipid metabolism. Drug-loaded lipoproteins can be delivered to the retina for the treatment of posterior eye diseases. In this review, we have discussed the therapeutic applications of lipoproteins for eye diseases and introduced the emerging animal models used for the evaluation of their therapeutic effects.
脂蛋白是天然存在的纳米颗粒，其主要生理功能是促进脂质代谢。它们可以在体外制备用于作为药物载体，这些重组脂蛋白表现出与其天然对应物相似的生物学活性。一些脂蛋白可以穿过血视网膜屏障，参与眼内脂质代谢。载药脂蛋白可以递送到视网膜以治疗眼后段疾病。在本综述中，我们讨论了脂蛋白在眼病治疗中的应用，并介绍了用于评估其治疗效果的新兴动物模型。
