Dragonas Panagiotis, El-Sioufi Iosif, Bobetsis Yiorgos A, Madianos Phoebus N
Oral Health Prev Dent. 2020 Apr 3;18(2):103-114. doi: 10.3290/j.ohpd.a44323.
To present a review of available literature on the association of vitamin D and periodontal disease.
A thorough search of articles was carried out on the databases PUBMED and MEDLINE regarding vitamin D and periodontal disease. The selected literature included cross-sectional, case-control and prospective and retrospective cohort studies. The main aspects of the association evaluated were a) the association of 25(OH)D and 1,25(OH)2D3 with periodontal disease severity, periodontal disease progression and tooth loss, b) the effect of vitamin D supplementation on periodontal health and c) the association of vitamin D receptor polymorphisms with periodontal disease. A brief overview of the biological mechanisms linking periodontal disease with vitamin D was also included.
There is conflicting evidence regarding the effects of 25(OH)D on periodontal disease severity, progression and tooth loss, with some studies reporting beneficial effects of higher 25(OH)D serum concentrations on periodontal health and tooth retention, whereas others could not find such an association. Limited evidence also supports a positive association between 1,25(OH)2D3 and periodontal health as well as a trend towards better periodontal health with vitamin D supplementation. Finally, various vitamin D polymorphisms were associated with chronic and aggressive periodontitis, with different outcomes reported for the various ethnic populations assessed.
对有关维生素D与牙周疾病关联的现有文献进行综述。
在PUBMED和MEDLINE数据库中对关于维生素D与牙周疾病的文章进行全面检索。所选文献包括横断面研究、病例对照研究以及前瞻性和回顾性队列研究。评估的关联主要方面包括：a）25（OH）D和1,25（OH）2D3与牙周疾病严重程度、牙周疾病进展和牙齿脱落的关联；b）维生素D补充剂对牙周健康的影响；c）维生素D受体多态性与牙周疾病的关联。还包括了将牙周疾病与维生素D联系起来的生物学机制的简要概述。
关于25（OH）D对牙周疾病严重程度、进展和牙齿脱落的影响，存在相互矛盾的证据，一些研究报告较高的25（OH）D血清浓度对牙周健康和牙齿保留有有益影响，而另一些研究则未发现这种关联。有限的证据也支持1,25（OH）2D3与牙周健康之间存在正相关，以及补充维生素D有使牙周健康状况改善的趋势。最后，各种维生素D多态性与慢性和侵袭性牙周炎相关，在评估的不同种族人群中报告了不同的结果。
