Gurban Camelia Vidiţa, Balaş Melania Olga, Vlad Mihaela Maria, Caraba Alexandru Emil, Jianu Adelina Maria, Bernad Elena Silvia, Borza Claudia, Bănicioiu-Covei Simona, Motoc Andrei Gheorghe Marius
Department of Anatomy and Embryology, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania;
Rom J Morphol Embryol. 2019;60(4):1127-1135.
Biochemical bone turnover markers (BTMs) estimates the bone remodeling process, being valuable in the personalized approach of osteoporotic patients.
The aim of the study was to evaluate the correlation between biochemical BTMs and bone mineral density (BMD), depending on menopause period, in postmenopausal osteoporotic women, compared to postmenopausal women without osteoporosis.
PATIENTS, MATERIALS AND METHODS: The study included 149 untreated postmenopausal women, divided into three groups: group 1 (65 osteoporotic women with less than 10 years of menopause), group 2 (44 osteoporotic patients, with over 10 years of menopause), and the control group with 40 postmenopausal women without osteoporosis.
All BTMs levels were higher in the groups with osteoporosis, than in the control group. Lumbar BMD values correlated positively with deoxypyridinoline (DPD) and negatively with bone-specific isoform of alkaline phosphatase (BAP), tartrate-resistant acid phosphatase band 5b (TRAP 5b), osteocalcin (OC) and cross-linked N-telopeptides of type I collagen (NTX). Serum estradiol levels correlated positively with spine BMD in the whole study group (r=0.508, p=0.001). BTMs correlated positively with each other. Osteoporotic women with longer period of menopause presented significantly higher values of resorption markers (NTX and TRAP 5b), compared to the group with menopause duration less than 10 years. At a cutoff value of 12 μg∕L, BAP presented 82.4% sensitivity and 62.5% specificity.
Our study showed that BTMs correlated negatively with lumbar BMD and positively with each other. Resorption markers levels increase with duration of estradiol deprivation period.
生化骨转换标志物（BTMs）可评估骨重塑过程，在骨质疏松患者的个性化治疗中具有重要价值。
本研究旨在评估绝经后骨质疏松女性与无骨质疏松的绝经后女性相比，根据绝经时间，生化BTMs与骨密度（BMD）之间的相关性。
患者、材料与方法：本研究纳入149例未经治疗的绝经后女性，分为三组：第1组（65例绝经少于10年的骨质疏松女性），第2组（44例绝经超过10年的骨质疏松患者），以及对照组40例无骨质疏松的绝经后女性。
骨质疏松组的所有BTMs水平均高于对照组。腰椎BMD值与脱氧吡啶啉（DPD）呈正相关，与骨特异性碱性磷酸酶同工型（BAP）、抗酒石酸酸性磷酸酶5b条带（TRAP 5b）、骨钙素（OC）和I型胶原交联N-端肽（NTX）呈负相关。在整个研究组中，血清雌二醇水平与脊柱BMD呈正相关（r=0.508，p=0.001）。BTMs之间呈正相关。与绝经持续时间少于10年的组相比，绝经时间较长的骨质疏松女性的骨吸收标志物（NTX和TRAP 5b）值显著更高。在截断值为12μg∕L时，BAP的敏感性为82.4%，特异性为62.5%。
我们的研究表明，BTMs与腰椎BMD呈负相关，且彼此之间呈正相关。骨吸收标志物水平随雌二醇缺乏期的延长而增加。
