在人胎儿胃肠道粘蛋白中鉴定出一种新型寡糖主链结构，其在C-6位有一个半乳糖残基单取代。
Identification of a novel oligosaccharide backbone structure with a galactose residue monosubstituted at C-6 in human foetal gastrointestinal mucins.
作者信息
Hounsell E F, Lawson A M, Feeney J, Cashmore G C, Kane D P, Stoll M, Feizi T
机构信息
Section of Glycoconjugate Research, Clinical Research Centre, Harrow, U.K.
出版信息
Biochem J. 1988 Dec 1;256(2):397-401. doi: 10.1042/bj2560397.
Abstract
An oligosaccharide purified from a major penta- to hexa-saccharide fraction of human meconium glycoproteins has been shown by m.s. and n.m.r. analysis to have a novel backbone structure containing an internal galactose residue monosubstituted at C-6 by N-acetylglucosamine: (Formula: see text). This oligosaccharide may represent a biosynthetic product of a previously unrecognized N-acetylglucosaminyltransferase catalysing formation of a linear GlcNAc beta 1-6Gal sequence.
摘要
从人胎粪糖蛋白的主要五糖至六糖级分中纯化得到的一种寡糖，经质谱（m.s.）和核磁共振（n.m.r.）分析表明，其具有一种新型主链结构，该结构包含一个在C-6位被N-乙酰葡糖胺单取代的内部半乳糖残基：（分子式：见正文）。这种寡糖可能代表一种先前未被识别的N-乙酰葡糖胺基转移酶的生物合成产物，该酶催化形成线性的GlcNAcβ1-6Gal序列。
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