Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environmental Sciences, The Hebrew University of Jerusalem, Rehovot, Israel.
Department for Restorative and Preventive Dentistry, Charité - Universitaetsmedizin Berlin, Berlin, Germany.
J Fish Biol. 2021 Apr;98(4):995-1006. doi: 10.1111/jfb.14334. Epub 2020 Apr 19.
Medaka (O. latipes) and zebrafish (D. rerio) are two teleost fish increasingly used as models to study human skeletal diseases. Although they are similar in size, swimming pattern and many other characteristics, these two species are very distant from an evolutionary point of view (by at least 100 million years). A prominent difference between the skeletons of medaka and zebrafish is the total absence of osteocytes in medaka (anosteocytic), while zebrafish bone contains numerous osteocytes (osteocytic). This fundamental difference suggests the possibility that the bony elements of their skeleton may be different in a variety of other aspects, structural, mechanical or both, particularly in heavily loaded bones like the vertebrae. Here we report on the results of a comparative study that aimed to determine the similarities and differences in medaka and zebrafish vertebrae in terms of their macro- to nanostructure, composition and mechanical properties. Our results reveal many similarities between medaka and zebrafish vertebrae, making the lack or presence of osteocytes the only major difference between the bones of these two species.
黄颡鱼（O. latipes）和斑马鱼（D. rerio）是两种常用于研究人类骨骼疾病的硬骨鱼模型。尽管它们在体型、游泳模式和许多其他特征上相似，但从进化的角度来看，这两个物种非常不同（至少相差 1 亿年）。黄颡鱼骨骼与斑马鱼骨骼的一个显著区别是黄颡鱼骨骼中完全没有骨细胞（无骨细胞），而斑马鱼骨骼中含有大量的骨细胞（有骨细胞）。这种根本的差异表明，它们骨骼的骨元素在结构、力学或两者兼有的各种其他方面可能存在差异，特别是在像脊椎骨这样的重负荷骨中。在这里，我们报告了一项比较研究的结果，该研究旨在确定黄颡鱼和斑马鱼脊椎骨在宏观到纳米结构、组成和力学性能方面的相似性和差异。我们的结果揭示了黄颡鱼和斑马鱼脊椎骨之间的许多相似之处，使得骨细胞的缺失或存在成为这两个物种骨骼之间唯一的主要区别。
