股外侧皮神经炎：神经刺激器引导下注射甲泼尼龙/利多卡因的双盲随机安慰剂对照研究。
Meralgia paresthetica: Nerve stimulator-guided injection with methylprednisolone/lidocaine, a double-blind randomized placebo-controlled study.
机构信息
Department of Neurology, Haga Hospital, The Hague, The Netherlands.
Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.
出版信息
Muscle Nerve. 2020 Jun;61(6):788-791. doi: 10.1002/mus.26877. Epub 2020 Apr 17.
BACKGROUND
Meralgia paresthetica is a mononeuropathy of the lateral femoral cutaneous nerve. A common therapy is injection with corticosteroids. The goal of this study was to analyze the effect of injection with methylprednisolone/lidocaine vs placebo.
METHODS
After randomization, 10 patients received a nerve stimulator-guided injection with methylprednisolone/lidocaine, and 10 patients received saline. The primary outcome measure was pain (visual analogue scale, VAS).
RESULTS
In the placebo group, there was a significant pain reduction (baseline VAS, 6.8; VAS week 12, 4.3; P = .014). The VAS score in the methylprednisolone group did not show a significant reduction (baseline VAS, 7.4; VAS week 12, 4.8; P = .053). There was no significant difference in pain reduction between the groups.
CONCLUSIONS
We found no objective evidence for benefit from nerve stimulator-guided injection with corticosteroids in meralgia paresthetica, although this study is limited by a small sample size. Future placebo-controlled studies using ultrasound-guided injection are warranted.
背景
股外侧皮神经炎是一种股外侧皮神经单神经病。一种常见的治疗方法是皮质类固醇注射。本研究的目的是分析甲泼尼龙/利多卡因注射与安慰剂的效果。
方法
随机分组后，10 名患者接受神经刺激器引导下甲泼尼龙/利多卡因注射，10 名患者接受生理盐水注射。主要观察指标为疼痛（视觉模拟评分，VAS）。
结果
在安慰剂组，疼痛明显减轻（基线 VAS，6.8；第 12 周 VAS，4.3；P =.014）。甲泼尼龙组 VAS 评分无明显降低（基线 VAS，7.4；第 12 周 VAS，4.8；P =.053）。两组疼痛缓解无显著差异。
结论
尽管本研究样本量较小，但我们没有发现神经刺激器引导下皮质类固醇注射治疗股外侧皮神经炎的客观证据。需要进行超声引导下注射的安慰剂对照研究。
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