An Yu, Wang Kun, Tian Jie
Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
Vis Comput Ind Biomed Art. 2018 Sep 5;1(1):1. doi: 10.1186/s42492-018-0001-6.
Molecular imaging (MI) is a novel imaging discipline that has been continuously developed in recent years. It combines biochemistry, multimodal imaging, biomathematics, bioinformatics, cell & molecular physiology, biophysics, and pharmacology, and it provides a new technology platform for the early diagnosis and quantitative analysis of diseases, treatment monitoring and evaluation, and the development of comprehensive physiology. Fluorescence Molecular Tomography (FMT) is a type of optical imaging modality in MI that captures the three-dimensional distribution of fluorescence within a biological tissue generated by a specific molecule of fluorescent material within a biological tissue. Compared with other optical molecular imaging methods, FMT has the characteristics of high sensitivity, low cost, and safety and reliability. It has become the research frontier and research hotspot of optical molecular imaging technology. This paper took an overview of the recent methodology advances in FMT, mainly focused on the photon propagation model of FMT based on the radiative transfer equation (RTE), and the reconstruction problem solution consist of forward problem and inverse problem. We introduce the detailed technologies utilized in reconstruction of FMT. Finally, the challenges in FMT were discussed. This survey aims at summarizing current research hotspots in methodology of FMT, from which future research may benefit.
分子成像（MI）是近年来不断发展的一门新型成像学科。它融合了生物化学、多模态成像、生物数学、生物信息学、细胞与分子生理学、生物物理学和药理学，为疾病的早期诊断和定量分析、治疗监测与评估以及综合生理学的发展提供了一个新技术平台。荧光分子断层成像（FMT）是分子成像中的一种光学成像方式，它能获取生物组织内由特定荧光物质分子产生的荧光的三维分布。与其他光学分子成像方法相比，FMT具有灵敏度高、成本低以及安全可靠的特点。它已成为光学分子成像技术的研究前沿和热点。本文综述了FMT近期的方法学进展，主要聚焦基于辐射传输方程（RTE）的FMT光子传播模型，以及由正向问题和逆问题组成的重建问题解决方案。我们介绍了FMT重建中使用的详细技术。最后，讨论了FMT面临的挑战。本综述旨在总结FMT方法学当前的研究热点，未来的研究可能会从中受益。
