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1
Screening faecal microbiota transplant donors for SARS-CoV-2 by molecular testing of stool is the safest way forward.通过对粪便进行分子检测来筛查严重急性呼吸综合征冠状病毒2（SARS-CoV-2）粪便微生物群移植供体是最安全的前进方式。
Lancet Gastroenterol Hepatol. 2020 Jun;5(6):531. doi: 10.1016/S2468-1253(20)30089-3. Epub 2020 Mar 30.
2
Screening FMT donors during the COVID-19 pandemic: a protocol for stool SARS-CoV-2 viral quantification.在2019冠状病毒病大流行期间筛查粪菌移植供体：粪便严重急性呼吸综合征冠状病毒2病毒定量方案
Lancet Gastroenterol Hepatol. 2020 Jul;5(7):642-643. doi: 10.1016/S2468-1253(20)30124-2. Epub 2020 Apr 22.
3
Cohort PCR Testing: A Strategic Method for Rapid SARS-CoV-2 Screening.队列聚合酶链反应检测：一种快速筛查严重急性呼吸综合征冠状病毒2的策略性方法。
Am J Clin Pathol. 2020 Jul 7;154(2):278-279. doi: 10.1093/ajcp/aqaa092.
4
Challenges and issues of SARS-CoV-2 pool testing.新型冠状病毒2019（SARS-CoV-2）混合检测的挑战与问题
Lancet Infect Dis. 2020 Nov;20(11):1233-1234. doi: 10.1016/S1473-3099(20)30467-9. Epub 2020 Jul 14.
5
Challenges and issues of SARS-CoV-2 pool testing.新型冠状病毒2019（SARS-CoV-2）混合检测的挑战与问题
Lancet Infect Dis. 2020 Nov;20(11):1233. doi: 10.1016/S1473-3099(20)30463-1. Epub 2020 Jul 14.
6
Challenges and issues of SARS-CoV-2 pool testing.新型冠状病毒2019（SARS-CoV-2）混合检测的挑战与问题
Lancet Infect Dis. 2020 Nov;20(11):1232-1233. doi: 10.1016/S1473-3099(20)30516-8. Epub 2020 Jul 14.
7
SARS-CoV-2 infection in liver transplant recipients: collaboration in the time of COVID-19.肝移植受者中的新型冠状病毒2型感染：COVID-19疫情下的合作
Lancet Gastroenterol Hepatol. 2020 Nov;5(11):958-960. doi: 10.1016/S2468-1253(20)30293-4. Epub 2020 Sep 18.
8
Asymptomatic coronavirus infection: MERS-CoV and SARS-CoV-2 (COVID-19).无症状冠状病毒感染：中东呼吸综合征冠状病毒和严重急性呼吸综合征冠状病毒2（新型冠状病毒肺炎）
Travel Med Infect Dis. 2020 May-Jun;35:101608. doi: 10.1016/j.tmaid.2020.101608. Epub 2020 Feb 27.
9
Challenges and issues of SARS-CoV-2 pool testing - Authors' reply.严重急性呼吸综合征冠状病毒2型混合检测的挑战与问题——作者回复
Lancet Infect Dis. 2020 Nov;20(11):1234-1235. doi: 10.1016/S1473-3099(20)30455-2. Epub 2020 Jul 14.
10
Safety Considerations in the Laboratory Testing of Specimens Suspected or Known to Contain the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).对疑似或已知含有严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的标本进行实验室检测时的安全注意事项。
Am J Clin Pathol. 2020 Apr 15;153(5):567-570. doi: 10.1093/ajcp/aqaa047.

引用本文的文献

1
Assuring safety of fecal microbiota transplantation in the COVID-19 era: A single-center experience.确保新冠肺炎疫情时代粪便微生物群移植的安全性：单中心经验
JGH Open. 2023 Oct 20;7(11):765-771. doi: 10.1002/jgh3.12979. eCollection 2023 Nov.
2
Rapid RT-PCR identification of SARS-CoV-2 in screening donors of fecal microbiota transplantation.在粪便微生物群移植筛查供体中对严重急性呼吸综合征冠状病毒2进行快速逆转录聚合酶链反应鉴定
Heliyon. 2023 Jun;9(6):e17438. doi: 10.1016/j.heliyon.2023.e17438. Epub 2023 Jun 18.
3
Faecal Microbiota Transplantation, Paving the Way to Treat Non-Alcoholic Fatty Liver Disease.粪便微生物移植，为治疗非酒精性脂肪性肝病铺平道路。
Int J Mol Sci. 2023 Mar 24;24(7):6123. doi: 10.3390/ijms24076123.
4
Application and development of fecal microbiota transplantation in the treatment of gastrointestinal and metabolic diseases: A review.粪便微生物群移植在治疗胃肠和代谢疾病中的应用和发展：综述。
Saudi J Gastroenterol. 2023 Jan-Feb;29(1):3-11. doi: 10.4103/sjg.sjg_131_22.
5
Current Trends and Challenges of Fecal Microbiota Transplantation-An Easy Method That Works for All?粪便微生物群移植的当前趋势与挑战——一种适用于所有人的简便方法？
Biomedicines. 2022 Oct 28;10(11):2742. doi: 10.3390/biomedicines10112742.
6
Effective Prophylaxis of COVID-19 in Rhesus Macaques Using a Combination of Two Parenterally-Administered SARS-CoV-2 Neutralizing Antibodies.使用两种经肠胃外给予的 SARS-CoV-2 中和抗体联合对恒河猴进行 COVID-19 的有效预防。
Front Cell Infect Microbiol. 2021 Nov 18;11:753444. doi: 10.3389/fcimb.2021.753444. eCollection 2021.
7
Coronavirus disease 2019 gastrointestinal and liver manifestations in adults: A review.2019年冠状病毒病成人胃肠道和肝脏表现：综述
JGH Open. 2021 Oct 26;5(11):1257-1265. doi: 10.1002/jgh3.12671. eCollection 2021 Nov.
8
Transmission of severe acute respiratory syndrome coronavirus 2 fecal-oral: Current knowledge.严重急性呼吸综合征冠状病毒2的粪口传播：当前认知
World J Clin Cases. 2021 Oct 6;9(28):8280-8294. doi: 10.12998/wjcc.v9.i28.8280.
9
High prevalence of extended-spectrum beta-lactamase organisms and the COVID-19 pandemic impact on donor recruitment for fecal microbiota transplantation in Hong Kong.香港产 ESBL 菌的高流行率和 COVID-19 大流行对粪便微生物移植供体招募的影响。
United European Gastroenterol J. 2021 Nov;9(9):1027-1038. doi: 10.1002/ueg2.12160. Epub 2021 Oct 8.
10
Multi-modality detection of SARS-CoV-2 in faecal donor samples for transplantation and in asymptomatic emergency surgical admissions.多模态检测粪便供体样本中的 SARS-CoV-2 用于移植和无症状急诊手术入院。
F1000Res. 2021 May 11;10:373. doi: 10.12688/f1000research.52178.1. eCollection 2021.

本文引用的文献

1
Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding.儿童感染 SARS-CoV-2 的特征及粪便中持续存在病毒的潜在证据。
Nat Med. 2020 Apr;26(4):502-505. doi: 10.1038/s41591-020-0817-4. Epub 2020 Mar 13.
2
Screening of faecal microbiota transplant donors during the COVID-19 outbreak: suggestions for urgent updates from an international expert panel.2019冠状病毒病疫情期间粪便微生物群移植供体的筛查：国际专家小组提出的紧急更新建议
Lancet Gastroenterol Hepatol. 2020 May;5(5):430-432. doi: 10.1016/S2468-1253(20)30082-0. Epub 2020 Mar 17.
3
Detection of SARS-CoV-2 in Different Types of Clinical Specimens.SARS-CoV-2 在不同类型临床标本中的检测。
JAMA. 2020 May 12;323(18):1843-1844. doi: 10.1001/jama.2020.3786.
4
Presumed Asymptomatic Carrier Transmission of COVID-19.新冠病毒无症状感染者的传播。
JAMA. 2020 Apr 14;323(14):1406-1407. doi: 10.1001/jama.2020.2565.
5
STOP-Colitis pilot trial protocol: a prospective, open-label, randomised pilot study to assess two possible routes of faecal microbiota transplant delivery in patients with ulcerative colitis.STOP-结肠炎试点试验方案：一项前瞻性、开放标签、随机试点研究，旨在评估溃疡性结肠炎患者粪便微生物群移植的两种可能给药途径。
BMJ Open. 2019 Nov 11;9(11):e030659. doi: 10.1136/bmjopen-2019-030659.
6
The use of faecal microbiota transplant as treatment for recurrent or refractory infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines.粪便微生物群移植作为治疗复发性或难治性感染及其他潜在适应证的应用：联合英国胃肠病学会（BSG）和医疗保健感染学会（HIS）指南。
Gut. 2018 Nov;67(11):1920-1941. doi: 10.1136/gutjnl-2018-316818. Epub 2018 Aug 28.

Screening faecal microbiota transplant donors for SARS-CoV-2 by molecular testing of stool is the safest way forward.

作者信息

Green Christopher A, Quraishi Mohammed N, Shabir Sahida, Sharma Naveen, Hansen Richard, Gaya Daniel R, Hart Ailsa L, Loman Nicholas J, Iqbal Tariq H

机构信息

University of Birmingham Microbiome Treatment Centre, Birmingham B15 2TT, UK; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.

University of Birmingham Microbiome Treatment Centre, Birmingham B15 2TT, UK; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

出版信息

Lancet Gastroenterol Hepatol. 2020 Jun;5(6):531. doi: 10.1016/S2468-1253(20)30089-3. Epub 2020 Mar 30.

DOI:10.1016/S2468-1253(20)30089-3
PMID:32240618
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7225406/
Abstract
摘要