Conte U, Colombo P, Gazzaniga A, Sangalli M E, La Manna A
Dipartimento di Chimica Farmaceutica, Università di Pavia, Italy.
Biomaterials. 1988 Nov;9(6):489-93. doi: 10.1016/0142-9612(88)90043-9.
A previous paper dealt with the preparation of an in vitro programmable zero-order drug delivery system in which the area of the surface exposed to the dissolution medium and the macromolecular relaxation of polymer controlled the release of the drug. In the present study, the preparation of similar delivery systems is described, in which differing drugs and polymers were used to ascertain the mechanism governing the drug-release kinetics. The movement of the interfaces between solvent and system was measured during drug release in systems with varying composition. The results indicate that the synchronization of the movement of swelling and eroding fronts at the solvent-system interface determines the achievement of the linear-release kinetics of such swelling activated systems and that the swelling and dissolution characteristics of the polymer employed for core preparation govern front movement.
先前的一篇论文论述了一种体外可编程零级药物递送系统的制备，其中暴露于溶解介质的表面积以及聚合物的大分子松弛控制着药物的释放。在本研究中，描述了类似递送系统的制备，其中使用了不同的药物和聚合物来确定控制药物释放动力学的机制。在具有不同组成的系统中，在药物释放过程中测量了溶剂与系统之间界面的移动。结果表明，溶剂 - 系统界面处溶胀前沿和侵蚀前沿移动的同步性决定了此类溶胀激活系统线性释放动力学的实现，并且用于制备核心的聚合物的溶胀和溶解特性控制着前沿移动。
