Höfeler H, Popescu O, Günther B, Schmidt U, Hornung G, Höffken K, Schmidt C G
Dtsch Med Wochenschr. 1987 Jun 12;112(24):963-6. doi: 10.1055/s-2008-1068176.
In a 44 year old patient with chronic lymphatic leukemia and secondary antibody deficiency syndrome, a disorder of articulation and a left hemiparesis developed during a thrombocytopenic phase. Computer tomography of the cranium, CSF diagnostics and the electroencephalogram did not provide any indication for the cause of the rapidly progressive cerebral symptoms. In the NMR tomogram, a diffusedly increasing intensity in the T2-weighted tomograms were shown around the central region in the right brain. The patient died of a Pseudomonas septicemia. At autopsy, a typical finding of progressive multifocal leukoencephalopathy was found in the areas altered in the NMR tomography. Papova-like virions could be demonstrated in glial cells by electron microscopy.
一名44岁患有慢性淋巴细胞白血病和继发性抗体缺乏综合征的患者，在血小板减少期出现构音障碍和左侧偏瘫。头颅计算机断层扫描、脑脊液诊断及脑电图检查均未提示导致快速进展性脑部症状的病因。在核磁共振断层扫描中，右侧脑中央区域周围的T2加权断层扫描显示强度呈弥漫性增加。患者死于铜绿假单胞菌败血症。尸检时，在核磁共振断层扫描显示有改变的区域发现了进行性多灶性白质脑病的典型表现。通过电子显微镜可在神经胶质细胞中发现乳头多瘤空泡病毒样病毒颗粒。
