Zachoval R, Hunstein W, Ho A D
Blut. 1980 Dec;41(6):451-4. doi: 10.1007/BF01007770.
This is a report on a 78-year-old patient with Hodgkin's disease of mixed cell type in stage III B, who, because of his age, underwent only mild cytostatic therapy. Two months after beginning of treatment, cerebellar neurological symptoms developed. He died of bronchopneumonia 3 months later. At autopsy progressive multifocal leukoencephalopathy with multiple demyelinated areas in the cerebellum was established. Paracristallinic structures within nuclei of glial cells resembling papovavirus formations were detected by electron microscopy.
这是一份关于一名78岁患有ⅢB期混合细胞型霍奇金病患者的报告。由于其年龄原因，该患者仅接受了轻度的细胞抑制疗法。治疗开始两个月后，出现了小脑神经症状。3个月后，他死于支气管肺炎。尸检发现为进行性多灶性白质脑病，小脑有多个脱髓鞘区域。通过电子显微镜检测到神经胶质细胞核内存在类似乳头多瘤空泡病毒结构的副晶状结构。
