挪威采用细胞学、HPV16/18 基因分型和 HPV 持续性对 HPV 阳性女性进行分类
Triage of HPV-positive women in Norway using cytology, HPV16/18 genotyping and HPV persistence.
机构信息
Unit of Cancer Epidemiology, Belgian Cancer Centre, Sciensano, Brussels, Belgium.
Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
出版信息
Br J Cancer. 2020 May;122(11):1577-1579. doi: 10.1038/s41416-020-0787-9. Epub 2020 Apr 3.
In a Norwegian pilot, triage of high-risk human papillomavirus (hrHPV)-positive women with reflex cytology followed by hrHPV testing 12 months later, yielded 82% of women referred to colposcopy and 24% with CIN3+. A policy stratified by the presence of HPV16/18 would be more efficient (66% referred to colposcopy) at the expense of small losses in the detection of precancer.
在挪威的一项试点研究中，对高危型人乳头瘤病毒（hrHPV）阳性的女性进行初筛，如果细胞学检查结果异常则行阴道镜检查，结果正常者 12 个月后复查 hrHPV，如果仍为阳性则再次行阴道镜检查，这种策略使得 82%的女性需要转诊行阴道镜检查，24%的女性发现 CIN3+。而如果根据 HPV16/18 的感染状态进行分层，虽然会有少量的癌前病变漏诊，但转诊行阴道镜检查的比例会更高（66%）。
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