Pommerrenig Benjamin, Müdsam Christina, Kischka Dominik, Neuhaus H Ekkehard
Plant Physiology, University of Kaiserslautern, Kaiserslautern, Germany.
Biochemistry, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
J Exp Bot. 2020 Jul 6;71(14):3930-3940. doi: 10.1093/jxb/eraa168.
Sugar transport proteins are crucial for the coordinated allocation of sugars. In this Expert View we summarize recent key findings of the roles and regulation of sugar transporters in inter- and intracellular transport by focusing on applied approaches, demonstrating how sucrose transporter activity may alter source and sink dynamics and their identities. The plant itself alters its sugar transport activity in a developmentally dependent manner to either establish or load endogenous sinks, for example, during tuber formation and filling. Pathogens represent aberrant sinks that trigger the plant to induce the same processes, resulting in loss of carbon assimilates. We explore common mechanisms of intrinsic, developmentally dependent processes and aberrant, pathogen-induced manipulation of sugar transport. Transporter activity may also be targeted by breeding or genetic modification approaches in crop plants to alter source and sink metabolism upon the overexpression or heterologous expression of these proteins. In addition, we highlight recent progress in the use of sugar analogs to study these processes in vivo.
糖转运蛋白对于糖的协调分配至关重要。在本专家观点中，我们通过聚焦应用方法总结了糖转运蛋白在细胞间和细胞内运输中的作用及调控的近期关键发现，展示了蔗糖转运蛋白活性如何改变源库动态及其特性。植物自身以发育依赖的方式改变其糖运输活性，以建立或加载内源性库，例如在块茎形成和充实过程中。病原体代表异常库，会触发植物诱导相同的过程，导致碳同化物的损失。我们探讨了内在的、发育依赖过程以及病原体诱导的异常糖运输操纵的共同机制。在作物中，通过育种或基因改造方法也可以靶向转运蛋白活性，在这些蛋白质过表达或异源表达时改变源库代谢。此外，我们强调了使用糖类似物在体内研究这些过程的最新进展。
