22q11 缺失综合征患者的社会认知缺陷与精神分裂症的遗传易感性。
Social cognition deficit and genetic vulnerability to schizophrenia in 22q11 deletion syndrome.
机构信息
Dipartimento di Neuroscienze Umane, Sapienza Università di Roma, Rome, Italy.
Dipartimento Materno Infantile e Scienze Urologiche, Sapienza Università di Roma, Rome, Italy.
出版信息
Ann Ist Super Sanita. 2020 Jan-Mar;56(1):107-113. doi: 10.4415/ANN_20_01_15.
INTRODUCTION
22q11.2 microdeletion syndrome (22q11DS) is associated with a 25% risk of psychotic onset.
MATERIALS AND METHODS
The sample consist of 120 subjects: 39 schizophrenics (SCZ); 20 siblings of schizophrenic patients (SIB); 34 22q11DS non-psychotic patients (DEL); 17 22q11DS psychotic patients (DEL_scz); 30 control subjects (CS). Social cognition was evaluated with the awareness of social interference test. Intelligence Quotient (IQ) was calculated with Wechsler Adult Intelligence Scale. TASIT (Awareness of Social Inference Test) performance was analyzed via MANOVA, including IQ as covariate.
RESULTS
Group and IQ showed significant effect (p < 0.001; p = 0.037). The only TASIT variables where IQ showed no effect were paradoxical sarcasm; sincerity; lie. In sincerity, CS group shows a better performance than both 22q11DS groups (p < 0.05). In paradoxical sarcasm and lie, CS group performed better than each clinical group (p < 0.05). Regarding lie, DEL group was worst also respect to SCZ group (p = 0.029).
CONCLUSIONS
Our results show a specific social cognition deficit in 22q11DS and schizophrenia.
简介
22q11.2 微缺失综合征（22q11DS）与 25%的精神病发病风险相关。
材料与方法
该样本由 120 名受试者组成：39 名精神分裂症患者（SCZ）；20 名精神分裂症患者的兄弟姐妹（SIB）；34 名 22q11DS 非精神病患者（DEL）；17 名 22q11DS 精神病患者（DEL_scz）；30 名对照组（CS）。社会认知通过社会干扰意识测试进行评估。智商（IQ）用韦氏成人智力量表计算。TASIT（社会认知意识测试）的表现通过 MANOVA 进行分析，包括 IQ 作为协变量。
结果
组间和 IQ 显示出显著的影响（p<0.001；p=0.037）。只有 TASIT 的变量中 IQ 没有影响的是矛盾讽刺；真诚；谎言。在真诚方面，CS 组的表现优于 22q11DS 组（p<0.05）。在矛盾讽刺和谎言方面，CS 组的表现优于每个临床组（p<0.05）。关于谎言，DEL 组也比 SCZ 组差（p=0.029）。
结论
我们的结果显示 22q11DS 和精神分裂症存在特定的社会认知缺陷。
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