Mitchell I J, Redgrave P, Dean P
Department of Psychology, University of Sheffield, U.K.
Brain Res. 1988 Sep 20;460(2):394-7. doi: 10.1016/0006-8993(88)90389-7.
Whereas a single microinjection of L-glutamate (10 nmol) into the cuneiform area of rats gives freezing, a second or third injection (delivered at 4-min intervals to the same site)can produce fast running. To examine whether this plasticity of response was caused by a simple increase in the amount of glutamate present, 30 nmol of glutamate were given in a single injection. In 93% of sites in the cuneiform area this procedure gave only freezing, although subsequent testing with repeated injections produced fast running in 53% of these sites. Thus, response potentiation to glutamate appears to require repeated stimulation, and may therefore be related to processes underlying the natural conditioning of defensive responses.
向大鼠楔状核区单次微量注射L - 谷氨酸（10纳摩尔）会引起僵住反应，而第二次或第三次注射（以4分钟的间隔注射到同一部位）会导致快速奔跑。为了研究这种反应的可塑性是否是由谷氨酸含量的简单增加引起的，单次注射了30纳摩尔的谷氨酸。在楔状核区93%的部位，这种操作只引起了僵住反应，尽管随后重复注射测试在这些部位的53%产生了快速奔跑。因此，对谷氨酸的反应增强似乎需要重复刺激，因此可能与防御反应自然条件作用的潜在过程有关。
