General Surgery Unit, Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
CKDnet, Khon Kaen University, Khon Kaen, Thailand.
Sci Rep. 2020 Oct 20;10(1):17765. doi: 10.1038/s41598-020-74669-7.
This research examined the relationship between colon cancer risks and pollution in various areas of Thailand, using satellites to gather quantities of aerosols in the atmosphere. Bayesian hierarchical spatio-temporal model and the Poisson log-linear model were used to examine the incidence rates of colon cancer standardized by national references; from the database of the National Health Security Office, Ministry of Public Health of Thailand and NASA's database from aerosol diagnostics model. Modern-Era Retrospective Analysis for Research and Applications, Version 2 (MERRA-2) was used to explore disease-gender-specific spatio-temporal patterns of colon cancer incidences and accumulated air pollution-related cancers in Thailand between 2010 and 2016. A total of 59,605 patients were selected for the study. Due to concerns regarding statistical reliability between aerosol diagnostics model and colon cancer incidences, the posterior probabilities of risk appeared the most in dust PM. It could be interpreted as relative risk in every increase of 10 μg/m in black carbon, organic carbon, and dust-PM levels were associated respectively with an increase of 4%, 4%, and 15% in the risks of colon cancer. A significant increase in the incidence of colon cancer with accumulated ambient air quality raised concerns regarding the prevention of air pollution. This study utilized data based on the incidences of colon cancer; the country's database and linked cancer data to pollution. According to the database from NASA's technology, this research has never been conducted in Thailand.
本研究利用卫星收集大气中的气溶胶数量,考察了泰国不同地区结肠癌风险与污染之间的关系。采用贝叶斯分层时空模型和泊松对数线性模型,以国家参考为标准,对结肠癌发病率进行了标准化检验;数据来源于泰国公共卫生部下属的国家健康保障办公室数据库和美国国家航空航天局(NASA)的气溶胶诊断模型数据库。利用现代回顾分析研究和应用(MERRA-2)模型,探索了 2010 年至 2016 年期间泰国结肠癌发病率与与累积空气污染相关癌症的疾病-性别特定时空模式。共选择了 59605 名患者进行研究。由于气溶胶诊断模型与结肠癌发病率之间的统计可靠性存在问题,尘埃 PM 的风险后验概率最高。可以解释为,在黑碳、有机碳和尘埃 PM 水平每增加 10μg/m 时,结肠癌的风险分别增加 4%、4%和 15%。结肠癌发病率的显著增加引起了对预防空气污染的关注。本研究利用了基于结肠癌发病率的国家数据库和关联癌症数据进行污染研究。这项研究利用了 NASA 技术的数据库,在泰国尚属首次。