快照：精准医学中的试验类型。

Snapshot: Trial Types in Precision Medicine.

机构信息

Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA; Taproot Health, Salt Lake City, UT, USA.

Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

出版信息

Cell. 2020 Apr 2;181(1):208-208.e1. doi: 10.1016/j.cell.2020.02.032.

DOI:10.1016/j.cell.2020.02.032

PMID:32243791

Abstract

Integrating precision diagnostics into personalized treatments requires understanding how biomarkers relate to clinical outcomes. Various clinical data collection methods exist, each with strengths and weaknesses. Interventional data are high quality but narrowly focused. Real-world data (RWD) provide broader information but with variable quality. Master protocols allow better efficiency in data collection. The master observational trial bridges the gap between interventional and retrospective RWD collection methods. To view this SnapShot, open or download the PDF.

摘要

将精准诊断整合到个性化治疗中需要了解生物标志物与临床结果的关系。存在各种临床数据收集方法，每种方法都有其优点和缺点。干预性数据质量高但针对性强。真实世界数据（RWD）提供更广泛的信息，但质量参差不齐。主方案允许更有效地收集数据。主观察性试验弥合了干预性和回顾性 RWD 收集方法之间的差距。要查看此快照，请打开或下载 PDF。