Wiklund L
Acta Anaesthesiol Scand. 1977;21(3):189-99. doi: 10.1111/j.1399-6576.1977.tb01209.x.
Fifteen healthy young volunteers were studied before and during an intravenous infusion of a local anaesthetic agent. Seven received bupivacaine and eight etidocaine in a dose rate of 2 mg/min over a period of 150 min. Variables of the central systemic circulation and also the hepatic blood flow were measured repeatedly. The circulatory alterations during administration of the two drugs were compared. Comparisons with previous results concerning lidocaine and a placebo were also made. It was found that bupivacaine increased the heart rate, mean arterial blood pressure and cardiac output significantly more than did etidocaine in an equal plasma concentration. Lidocaine was intermediate between bupivacaine and etidocaine. In contrast, these three drugs had the same decreasing effect upon the splanchnic vascular resistance, which caused an almost identical increase in the estimated hepatic blood flow. The calculated vascular resistance in the systemic circulation, excluding the splanchnic, was unchanged during the infusion of etidocaine, while it decreased during the infusion of bupivacaine. Most of this discrepancy was due to the different plasma concentrations of the drugs.
对15名健康青年志愿者在静脉输注局部麻醉剂之前和期间进行了研究。7名志愿者接受布比卡因，8名接受依替卡因，以2毫克/分钟的剂量率持续输注150分钟。反复测量中心体循环变量以及肝血流量。比较了两种药物给药期间的循环变化。还与先前关于利多卡因和安慰剂的结果进行了比较。结果发现，在相同血浆浓度下，布比卡因比依替卡因显著更能增加心率、平均动脉血压和心输出量。利多卡因的作用介于布比卡因和依替卡因之间。相比之下，这三种药物对内脏血管阻力具有相同的降低作用，这导致估计的肝血流量几乎相同地增加。在输注依替卡因期间，不包括内脏的体循环中计算出的血管阻力没有变化，而在输注布比卡因期间则降低。这种差异大部分是由于药物的血浆浓度不同所致。
