Bandera M, Fioretti M, Rimoldi R, Lazzarini A, Anelli M
Pneumology Dept., Ospedale Civile, Varese, Italy.
Chemioterapia. 1988 Oct;7(5):313-6.
A clinical trial, involving 16 male subjects affected by a relapse of chronic bronchitis, was performed in order to evaluate the possible interference of roxithromycin (RU 28965) with theophylline plasma levels. Theophylline was administered to patients as a controlled release formulation. Results did not show any clinically relevant change in theophylline blood levels, implying the conclusion that the new macrolide roxithromycin can be administered simultaneously with a controlled release theophylline.
为评估罗红霉素（RU 28965）对茶碱血药浓度的可能干扰，对16名慢性支气管炎复发的男性受试者进行了一项临床试验。茶碱以控释制剂的形式给予患者。结果显示茶碱血药浓度没有出现任何具有临床意义的变化，这意味着可以得出新的大环内酯类药物罗红霉素可与控释茶碱同时给药的结论。
