Bartolucci L, Gradoli C, Vincenzi V, Iapadre M, Valori C
Chemioterapia. 1984 Oct;3(5):286-90.
Ten patients with exacerbated chronic asthmatic bronchitis, subdivided into two groups on the basis of respiratory failure, were treated with theophylline-ethylendiamine administered by continuous venous infusion (0.7 mg/kg/hr over a period of 132 hrs). The aim of the study was the evaluation of serum theophylline levels during administration of erythromycin or josamycin (500 mg q.i.d. orally for 48) hours). An increase of theophylline levels was registered during erythromycin treatment in the group of patients with greater impairment of the respiratory function, while in the other group no significant change was observed. During josamycin treatment serum theophylline concentrations did not show any increase in both groups and, moreover, a significant reduction (p less than 0.05) was observed in the more seriously ill patients.
10例慢性哮喘性支气管炎急性加重患者，根据呼吸衰竭情况分为两组，接受静脉持续输注氨茶碱-乙二胺治疗（132小时内0.7mg/kg/小时）。该研究的目的是评估在给予红霉素或交沙霉素（口服500mg，每日4次，共48小时）期间的血清茶碱水平。在呼吸功能损害较重的患者组中，红霉素治疗期间茶碱水平升高，而另一组未观察到显著变化。在交沙霉素治疗期间，两组血清茶碱浓度均未升高，此外，病情较重的患者中观察到显著降低（p<0.05）。
