Martinelli D, Mazzei T, Fallani S, Palendri G, Novelli A, Periti P
USL 18, Div. Oculistica, Ospedale di Empoli, Italy.
Chemioterapia. 1988 Oct;7(5):317-9.
The aqueous humor penetration of the third-generation cephalosporin, ceftizoxime, was determined in 21 patients awaiting cataract extraction, after an intravenous bolus injection of 2 g. The beta-lactam compound achieved a mean peak aqueous humor concentration of 7.8 mg/l two hours after administration with a serum/humor percent ratio ranging between 7 and 16% during the four-hour sampling interval. Therefore, ceftizoxime levels in this extravascular fluid were above the minimum inhibitory concentrations for the majority of sensitive organisms.
在21例等待白内障摘除的患者静脉推注2克第三代头孢菌素头孢唑肟后，测定了其房水渗透性。这种β-内酰胺化合物在给药后两小时达到房水平均峰值浓度7.8毫克/升，在四小时采样间隔期间血清/房水百分比在7%至16%之间。因此，这种血管外液中的头孢唑肟水平高于大多数敏感生物体的最低抑菌浓度。
