旋毛虫感染过程中IgG亚类和IgE的相继出现。
The sequential appearance of IgG subclasses and IgE during the course of Trichinella spiralis infection.
作者信息
Ljungström I, Hammarström L, Kociecka W, Smith C I
机构信息
Department of Parasitology, National Bacteriological Laboratory, Stockholm, Sweden.
出版信息
Clin Exp Immunol. 1988 Nov;74(2):230-5.
Earlier studies have shown that IgG1 and IgG4 are the dominant IgG subclasses in the specific response during a chronic helminthic infection. It has also been suggested that IgG4 production results from chronic or repetitive antigenic stimulation and a correlation between IgG4 and IgE levels exists. An outbreak of Trichinella spiralis infection in Poland provided the opportunity to follow the sequential appearance of the IgG subclass and IgE responses in 15 patients during the early stage of Trichinella infection and to compare these observations in sera obtained one year later from the same patients. The results show that the sequential appearance of the IgG subclasses were IgG1 before IgG3 and IgG3 before IgG4. IgG1 antibodies dominated the immune response in all patients. A statistically significant increase in the number of IgG4 positive sera was observed in patients during the chronic stage compared to the findings during the early stage of infection (13% vs 73%; p less than 0.001), supporting the view that IgG4 results from a chronic antigenic stimulation. A correlation between the appearance of IgG4 and IgE was not found. The highest levels of IgE were seen in the first serum samples obtained, with a decrease during the course of infection.
早期研究表明，IgG1和IgG4是慢性蠕虫感染特异性反应中的主要IgG亚类。也有人提出，IgG4的产生源于慢性或重复性抗原刺激，且IgG4与IgE水平之间存在相关性。波兰爆发的旋毛虫感染为观察15例患者在旋毛虫感染早期IgG亚类和IgE反应的先后出现情况以及比较一年后从同一患者获得的血清中的这些观察结果提供了机会。结果显示，IgG亚类的先后出现顺序为IgG1先于IgG3，IgG3先于IgG4。IgG1抗体在所有患者的免疫反应中占主导地位。与感染早期的结果相比，在慢性期患者中观察到IgG4阳性血清数量有统计学意义的增加（13%对73%；p小于0.001），支持了IgG4源于慢性抗原刺激的观点。未发现IgG4与IgE出现之间的相关性。在获得的首批血清样本中IgE水平最高，在感染过程中有所下降。
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