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封装用于癌症治疗。

Encapsulation for Cancer Therapy.

机构信息

Department of Chemical Engineering, Universitat Rovira i Virgili, Av. Països Catalans 26, Campus Sescelades, 43007 Tarragona, Spain.

Department of Tissue Engineering Chair of Urology, Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun, Karlowicza St. 24, 85-092 Bydgoszcz, Poland.

出版信息

Molecules. 2020 Mar 31;25(7):1605. doi: 10.3390/molecules25071605.

DOI:10.3390/molecules25071605
PMID:32244513
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7180689/
Abstract

The current rapid advancement of numerous nanotechnology tools is being employed in treatment of many terminal diseases such as cancer. Nanocapsules (NCs) containing an anti-cancer drug offer a very promising alternative to conventional treatments, mostly due to their targeted delivery and precise action, and thereby they can be used in distinct applications: as biosensors or in medical imaging, allowing for cancer detection as well as agents/carriers in targeted drug delivery. The possibility of using different systems-inorganic nanoparticles, dendrimers, proteins, polymeric micelles, liposomes, carbon nanotubes (CNTs), quantum dots (QDs), biopolymeric nanoparticles and their combinations-offers multiple benefits to early cancer detection as well as controlled drug delivery to specific locations. This review focused on the key and recent progress in the encapsulation of anticancer drugs that include methods of preparation, drug loading and drug release mechanism on the presented nanosystems. Furthermore, the future directions in applications of various nanoparticles are highlighted.

摘要

当前，许多纳米技术工具的快速发展正在被应用于治疗许多绝症，如癌症。含有抗癌药物的纳米胶囊（NCs）为传统治疗方法提供了非常有前途的替代方案，这主要是由于它们的靶向输送和精确作用，因此它们可以用于不同的应用：作为生物传感器或在医学成像中，用于癌症检测以及作为靶向药物输送的试剂/载体。使用不同系统-无机纳米粒子、树枝状大分子、蛋白质、聚合物胶束、脂质体、碳纳米管（CNTs）、量子点（QDs）、生物聚合物纳米粒子及其组合的可能性为早期癌症检测以及向特定位置的药物输送提供了多种好处。本综述重点介绍了抗癌药物包封的关键和最新进展，包括所提出的纳米系统的制备方法、药物负载和药物释放机制。此外，还强调了各种纳米粒子应用的未来方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac8/7180689/e8a89411cb3d/molecules-25-01605-g016.jpg
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