Qin Lili, Zhao Xinyu, He Yiwei, Wang Hongqiang, Wei Hanjing, Zhu Qiong, Zhang Ting, Qin Yao, Du Ai
Sports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.
School of Physics Science and Engineering, Tongji University, Shanghai 200092, China.
Materials (Basel). 2020 Apr 1;13(7):1624. doi: 10.3390/ma13071624.
Resveratrol is a natural active ingredient found in plants, which is a polyphenolic compound and has a variety of pharmaceutical uses. Resveratrol-loaded TEMPO-oxidized cellulose aerogel (RLTA) was prepared using a freeze-drying method, employing high speed homogenization followed by rapid freezing with liquid nitrogen. RLTAs were designed at varying drug-cellulose aerogel ratios (1:2, 2:3, 3:2, and 2:1). It could be seen via scanning electron microscopy (SEM) that Res integrated into TEMPO-oxidized cellulose (TC) at different ratios, which changed its aggregation state and turned it into a short rod-like structure. Fourier transform infrared (FTIR) spectra confirmed that the RLTAs had the characteristic peaks of TC and Res. In addition, X-ray diffraction (XRD) demonstrated that the grain size of RLTA was obviously smaller than that of pure Res. RLTAs also had excellent stability in both simulated gastric fluid and phosphate buffer solution. The drug release rate was initially completed within 5 h under a loading rate of 30.7 wt%. The results of an MTT assay showed the low toxicity and good biocompatibility of the RLTAs. TC aerogel could be a promising drug carrier that may be widely used in designing and preparing novel biomedicine.
白藜芦醇是一种存在于植物中的天然活性成分，它是一种多酚类化合物，具有多种药用用途。采用冷冻干燥法，先进行高速均质，再用液氮快速冷冻，制备了负载白藜芦醇的TEMPO氧化纤维素气凝胶（RLTA）。RLTA的设计采用了不同的药物-纤维素气凝胶比例（1:2、2:3、3:2和2:1）。通过扫描电子显微镜（SEM）可以看出，白藜芦醇以不同比例整合到TEMPO氧化纤维素（TC）中，这改变了其聚集状态，使其变成短棒状结构。傅里叶变换红外（FTIR）光谱证实RLTA具有TC和白藜芦醇的特征峰。此外，X射线衍射（XRD）表明RLTA的晶粒尺寸明显小于纯白藜芦醇。RLTA在模拟胃液和磷酸盐缓冲溶液中也具有优异的稳定性。在30.7 wt%的负载率下，药物释放率最初在5小时内完成。MTT分析结果表明RLTA具有低毒性和良好的生物相容性。TC气凝胶可能是一种有前途的药物载体，可广泛用于新型生物医学的设计和制备。
